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Intraluminal Heal Recovery of Pancreatic Polypeptide
David W. McFadden, MD;
Marek Rudnicki, MD, PhD;
Ambikaipakan Balasubramaniam, PhD;
Josef E. Fischer, MD
Arch Surg. 1991;126(8):1032-1035.
Abstract
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• Pancreatic polypeptide (PP) is a normal constituent of pancreatic islet cells. Enterocytes containing PP have been identified but incompletely characterized. We previously demonstrated independent intravascular and intraluminal release of two related peptides, peptide YY and neuropeptide Y. In this study, using ileal segments in conscious dogs, we evaluated the intravascular and ileal intraluminal presence of PP to test meals. Fasted plasma and recoverable ileal PP concentrations averaged 139±2 and 65±4 pg/mL, respectively. A mixed protein meal resulted in a sustained rise of circulating PP levels associated with a brief elevation of ileal luminal PP levels. Fat meals were followed by elevations in plasma PP levels without luminal changes. Glucose ingestion altered neither plasma nor luminal PP levels. Our data support the existence of ileal PP-containing cells that respond independently of circulatory PP-releasing cells to different ingested stimuli.
(Arch Surg. 1991;126:1032-1035)
Author Affiliations
From the Departments of Surgery, University of Cincinnati College of Medicine and Veterans Affairs Medical Center, Cincinnati, Ohio.
Footnotes
Accepted for publication April 7, 1991.
Presented as a poster at the 73rd Annual Federation of American Societies for Experimental Biology Meeting, New Orleans, Louisiana, March 21, 1989.
Reprint requests to Department of Surgery, University of Cincinnati College of Medicine, 231 Bethesda Ave (ML 558), Cincinnati, OH 45267-0558 (Dr McFadden).
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