This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

J. Arthur Jensen, MD; William H. Goodson, MD; Harriet Williams Hopf, MD; Thomas K. Hunt, MD

Arch Surg. 1991;126(9):1131-1134.

Abstract
• Subcutaneous wound-tissue oxygen (Psqo₂) tension in eight volunteers fell rapidly and significantly in response to smoking, and remained low for 30 to 50 minutes. Sham "smoking" had no effect. These data suggest that a typical "pack-per-day" smoker experiences tissue hypoxia during a significant portion of each day. The degree of hypoxia found in these subjects has been associated with poor wound healing in animal and human studies. The onset and duration of tissue hypoxia paralleled the well-established plasma pharmacokinetics of nicotine. This suggests that peripheral vasoconstriction, induced by the adrenergic effects of nicotine, may contribute to the observed decrease in Psqo₂.

(Arch Surg. 1991;126:1131-1134)

Author Affiliations
From the Departments of Surgery (Drs Jensen, Goodson, and Hunt), and Anesthesia (Dr Hopf), University of California, San Francisco. Dr Jensen is now with the Breast Center, Van Nuys, Calif.

Footnotes
Accepted for publication May 19, 1991.

Reprint requests to the Department of Surgery, University of California, San Francisco, San Francisco, CA 94143-0522 (Dr Hunt).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Failure of Fracture Plate Fixation
Gardner et al.
J Am Acad Orthop Surg 2009;17:647-657.
ABSTRACT | FULL TEXT  

Smoking and alcohol intervention before surgery: evidence for best practice
Tonnesen et al.
Br J Anaesth 2009;102:297-306.
ABSTRACT | FULL TEXT  

Surgical Treatment of Early Wound Complications Following Primary Total Knee Arthroplasty
Galat et al.
JBJS 2009;91:48-54.
ABSTRACT | FULL TEXT  

Transdermal Oxygen Does Not Improve Sternal Wound Oxygenation in Patients Recovering from Cardiac Surgery
Bakri et al.
Anesth. Analg. 2008;106:1619-1626.
ABSTRACT | FULL TEXT  

Nicotine Delays Tendon-to-Bone Healing in a Rat Shoulder Model
Galatz et al.
JBJS 2006;88:2027-2034.
ABSTRACT | FULL TEXT  

Hypercapnia improves tissue oxygenation in morbidly obese surgical patients.
Hager et al.
Anesth. Analg. 2006;103:677-681.
ABSTRACT | FULL TEXT  

Tissue oxygenation response to mild hypercapnia during cardiopulmonary bypass with constant pump output
Akca et al.
Br J Anaesth 2006;96:708-714.
ABSTRACT | FULL TEXT  

Supplemental Perioperative Oxygen and the Risk of Surgical Wound Infection: A Randomized Controlled Trial
Belda et al.
JAMA 2005;294:2035-2042.
ABSTRACT | FULL TEXT  

Effects of Nicotine on Human Luteal Cells In Vitro: A Possible Role on Reproductive Outcome for Smoking Women
Miceli et al.
Biol. Reprod. 2005;72:628-632.
ABSTRACT | FULL TEXT  

Smoking Is a Risk Factor for Incisional Hernia
Sorensen et al.
Arch Surg 2005;140:119-123.
ABSTRACT | FULL TEXT  

Supplemental Oxygen and Carbon Dioxide Each Increase Subcutaneous and Intestinal Intramural Oxygenation
Ratnaraj et al.
Anesth. Analg. 2004;99:207-211.
ABSTRACT | FULL TEXT  

The Effects of Epidural and General Anesthesia on Tissue Oxygenation
Treschan et al.
Anesth. Analg. 2003;96:1553-1557.
ABSTRACT | FULL TEXT  

The Musculoskeletal Effects of Smoking
Porter and Hanley
J Am Acad Orthop Surg 2001;9:9-17.
ABSTRACT | FULL TEXT  

Subcutaneous Perfusion and Oxygen During Acute Severe Isovolemic Hemodilution in Healthy Volunteers
Hopf et al.
Arch Surg 2000;135:1443-1449.
ABSTRACT | FULL TEXT  

The Influence of 2 Surgical Bandage Systems on Wound Tissue Oxygen Tension
Plattner et al.
Arch Surg 2000;135:818-822.
ABSTRACT | FULL TEXT  

Perioperative Collagen Deposition in Elderly and Young Men and Women
Lenhardt et al.
Arch Surg 2000;135:71-74.
ABSTRACT | FULL TEXT  

Wound Tissue Oxygen Tension Predicts the Risk of Wound Infection in Surgical Patients
Hopf et al.
Arch Surg 1997;132:997-1004.
ABSTRACT  

Perioperative Normothermia to Reduce the Incidence of Surgical-Wound Infection and Shorten Hospitalization
Kurz et al.
NEJM 1996;334:1209-1216.
ABSTRACT | FULL TEXT