Cigarette Smoking Decreases Tissue Oxygen

doi:10.1001/archsurg.1991.01410330093013

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Vol. 126 No. 9, September 1991

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Cigarette Smoking Decreases Tissue Oxygen

J. Arthur Jensen, MD; William H. Goodson, MD; Harriet Williams Hopf, MD; Thomas K. Hunt, MD

Arch Surg. 1991;126(9):1131-1134.

Abstract

• Subcutaneous wound-tissue oxygen (Psqo₂) tension in eightvolunteers fell rapidly and significantly in response to smoking,and remained low for 30 to 50 minutes. Sham "smoking" had noeffect. These data suggest that a typical "pack-per-day" smokerexperiences tissue hypoxia during a significant portion of eachday. The degree of hypoxia found in these subjects has beenassociated with poor wound healing in animal and human studies.The onset and duration of tissue hypoxia paralleled the well-establishedplasma pharmacokinetics of nicotine. This suggests that peripheralvasoconstriction, induced by the adrenergic effects of nicotine,may contribute to the observed decrease in Psqo₂.

(Arch Surg. 1991;126:1131-1134)

Author Affiliations

From the Departments of Surgery (Drs Jensen, Goodson, and Hunt), and Anesthesia (Dr Hopf), University of California, San Francisco. Dr Jensen is now with the Breast Center, Van Nuys, Calif.

Footnotes

Accepted for publication May 19, 1991.

Reprint requests to the Department of Surgery, University ofCalifornia, San Francisco, San Francisco, CA 94143-0522 (DrHunt).

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