This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (16)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Miguel F. Herrera, MD; Elaine Stone, MD; Mervyn Deitel, MD; Sylvia L. Asa, MD, PhD

Arch Surg. 1992;127(1):105-108.

Abstract
• Pheochromocytomas may produce several vasoactive peptides. We studied a 39-year-old man who presented with paroxysmal flushing and abdominal pain with normal blood pressure. Laboratory and radiologic studies established the diagnosis of right adrenal pheochromocytoma, and histologic and ultrastructural examination showed the tumor to be a typical pheochromocytoma. Tissue culture yielded large quantities of norepinephrine and epinephrine. However, immunohistochemical studies, tissue assays, and in vitro cultures documented production of several peptides, including calcitonin gene-related peptide and vasoactive intestinal polypeptide in tumor cells. The patient has been asymptomatic after tumor resection. Production of multiple peptides by this tumor may account for the flushing and lack of hypertension, despite elevated catecholamine levels in this patient.

(Arch Surg. 1992;127:105-108)

Author Affiliations
From the Departments of Surgery (Drs Herrera and Deitel), Nutritional Sciences (Dr Deitel), Medicine (Endocrinology) (Dr Stone), and Pathology (Dr Asa), University of Toronto, St Joseph's Health Centre, and St Michael's Hospital, Toronto, Ontario.

Footnotes
Accepted for publication July 18, 1991.

Reprint requests to St Joseph's Health Centre Research Foundation, 30 The Queensway, Toronto, Ontario, Canada M6R 1B5 (Dr Deitel).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Hypokalemic Rhabdomyolysis due to WDHA Syndrome Caused by VIP-producing Composite Pheochromocytoma: A Case in Neurofibromatosis Type 1
Onozawa et al.
Jpn J Clin Oncol 2005;35:559-563.
ABSTRACT | FULL TEXT  

Pheochromocytoma Producing Vasoactive Intestinal Peptide
Smith et al.
Mayo Clin Proc. 2002;77:97-100.
ABSTRACT  

Immunohistochemical Evaluation of a Malignant Pheochromocytoma in a Wolfdog
Sako et al.
Vet Pathol 2001;38:447-450.
ABSTRACT | FULL TEXT  

Oncocytic Pheochromocytoma with Cytokeratin Reactivity: A Case Report with Immunohistochemical and Ultrastructural Studies
Wang et al.
INT J SURG PATHOL 1997;5:61-67.
ABSTRACT  

Diverted by the Chief Complaint
Pauker et al.
NEJM 1995;333:45-48.
FULL TEXT