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Possible Implications in Burn Patients

Daohong Zhou, MD; Andrew M. Munster, MD; Richard A. Winchurch, PhD

Arch Surg. 1992;127(1):65-69.

Abstract
• Certain disease states are associated with abnormal increases in the monokine interleukin 6. Increased levels of interleukin 6 have been demonstrated in serum from patients with burns and are associated with systemic increases in endotoxin levels. Using a murine in vitro experimental model, we have studied the effects of interleukin 6 on various measures of immunity. Our data indicate that levels equivalent to the concentrations found in serum of burn victims inhibit T-cell proliferation. The inhibitory effect is dose and time dependent, is specific for T cells, is not due to impairment of interleukin 2 production or of interleukin 2 receptor expression, and is dependent on macrophages. These data suggest that extraordinary increases in interleukin 6 levels may be related to impaired T-cell responses and to an increased susceptibility to infection in the patient with burns.

(Arch Surg. 1992;127:65-69)

Author Affiliations
From the Baltimore Regional Burn Center, The Johns Hopkins University School of Medicine, Baltimore, Md.

Footnotes
Accepted for publication August 14, 1991.

Read before the 11th Annual Meeting of the Surgical Infection Society, Fort Lauderdale, Fla, April 9, 1991.

Reprint requests to Asthma and Allergy Center, The Johns Hopkins University, 301 Bayview Blvd, Baltimore, MD 21224 (Dr Winchurch).

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