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A Multicenter Trial

Antonio J. Torres, MD; José I. Landa, MD; Mariano Moreno-Azcoita, MD; Jesús M. Argüello, MD; Gianfranco Silecchia, MD; José Castro, MD; Francisco Hernandez-Merlo, MD; José M. Jover, MD; Enrique Moreno-Gonzales, MD; José L. Balibrea, PhD

Arch Surg. 1992;127(1):97-100.

Abstract
• To evaluate the effectiveness of treatment with total parenteral nutrition (TPN) alone (group A) or combined with continuous intravenous infusion of somatostatin (group B) in postoperative gastrointestinal fistulas, a multicenter, controlled and prospective randomized trial was designed. We present the results obtained after the evaluation of 40 cases (group A, n = 20; group B, n = 20). No significant differences among these treatment schedules were observed in the percentage of closure of fistulas (group A, 81.25%; group B, 85%), but patients treated with total parenteral nutrition plus somatostatin had the fistulas close within a significantly shorter period of time. Moreover, this treatment was associated with a significantly lower morbidity. These preliminary results indicate that somatostatin is a useful therapeutic complement in the conservative treatment of patients with gastrointestinal fistulas.

(Arch Surg. 1992;127:97-100)

Author Affiliations
From the Departments of Surgery, The University Hospital of San Carlos (Drs Torres, Argüello, Hernandez-Merlo, and Balibrea), The Red Cross Hospital (Drs Moreno-Azcoita and Jover), The 12th of October Hospital (Drs Landa and Moreno-Gonzales), Madrid, Spain, and the Umberto I Hospital (Dr Silecchia), Rome, Italy.

Footnotes
Accepted for publication August 3, 1991.

Reprint requests to Hospital Universitario San Carlos, II Department of Surgery (3a Sur), c/Martin Lagos s/n, Cuidad Universitaria, 28040-Madrid, Spain (Dr Torres).

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