 |
 |

Somatostatin in the Management of Gastrointestinal FistulasA Multicenter Trial
Antonio J. Torres, MD;
José I. Landa, MD;
Mariano Moreno-Azcoita, MD;
Jesús M. Argüello, MD;
Gianfranco Silecchia, MD;
José Castro, MD;
Francisco Hernandez-Merlo, MD;
José M. Jover, MD;
Enrique Moreno-Gonzales, MD;
José L. Balibrea, PhD
Arch Surg. 1992;127(1):97-100.
Abstract
To evaluate the effectiveness of treatment with total parenteral nutrition (TPN) alone (group A) or combined with continuous intravenous infusion of somatostatin (group B) in postoperative gastrointestinal fistulas, a multicenter, controlled and prospective randomized trial was designed. We present the results obtained after the evaluation of 40 cases (group A, n = 20; group B, n = 20). No significant differences among these treatment schedules were observed in the percentage of closure of fistulas (group A, 81.25%; group B, 85%), but patients treated with total parenteral nutrition plus somatostatin had the fistulas close within a significantly shorter period of time. Moreover, this treatment was associated with a significantly lower morbidity. These preliminary results indicate that somatostatin is a useful therapeutic complement in the conservative treatment of patients with gastrointestinal fistulas.
(Arch Surg. 1992;127:97-100)
Author Affiliations
From the Departments of Surgery, The University Hospital of San Carlos (Drs Torres, Argüello, Hernandez-Merlo, and Balibrea), The Red Cross Hospital (Drs Moreno-Azcoita and Jover), The 12th of October Hospital (Drs Landa and Moreno-Gonzales), Madrid, Spain, and the Umberto I Hospital (Dr Silecchia), Rome, Italy.
Footnotes
Accepted for publication August 3, 1991.
Reprint requests to Hospital Universitario San Carlos, II Department of Surgery (3a Sur), c/Martin Lagos s/n, Cuidad Universitaria, 28040-Madrid, Spain (Dr Torres).
CiteULike Connotea Del.icio.us Digg Reddit Technorati Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
 |
Guidelines for the Use of Parenteral and Enteral Nutrition in Adult and Pediatric Patients
American Society for Parenteral and Enteral Nutrit
JPEN J Parenter Enteral Nutr 2002;26:1SA-138SA.
Role of somatostatin-14 and its analogues in the management of gastrointestinal fistulae: clinical data
Hesse et al.
Gut 2001;49:iv11-20.
ABSTRACT
| FULL TEXT
Optimising the treatment of upper gastrointestinal fistulae
Gonzalez-Pinto and Gonzalez
Gut 2001;49:iv21-28.
ABSTRACT
| FULL TEXT
Somatostatin in the Treatment of Chylothorax
Demos et al.
Chest 2001;119:964-966.
ABSTRACT
| FULL TEXT
Nutrition Support of Patients With Enterocutaneous Fistulas
Fukuchi et al.
Nutr Clin Pract 1998;13:59-65.
Can Octreotide Be Added to Parenteral Nutrition Solutions? Point--Counterpoint
Nutr Clin Pract 1998;13:84-88.
Invited Review: Nutrition Support in Pancreatitis
Marulendra and Kirby
Nutr Clin Pract 1995;10:45-53.
ABSTRACT
Somatostatin in gastroenterology More studies needed
Carlson et al.
BMJ 1994;309:604-604.
FULL TEXT
Somatostatin in gastroenterology
Shulkes and Wilson
BMJ 1994;308:1381-1382.
FULL TEXT
Clinical Rounds With Nutrition Support Services* From The Cleveland Clinic
Steiger et al.
Nutr Clin Pract 1993;8:282-290.
Somatostatin in the Management of Gastrointestinal Fistulas
EMORY et al.
Arch Surg 1992;127:1365-1365.
ABSTRACT
|