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John A. Johnkoski, MD; Shei-Pon Tzung, MD; Ralph J. Doerr, MD; Stefan A. Cohen, PhD

Arch Surg. 1992;127(11):1325-1329.

Abstract
• To examine the effect of a single hepatic focus of metastatic colon tumor on the immune function of liver nonparenchymal cells (NPCs) from C57Bl/6 mice, we injected 2.5x10⁵ liver-derived murine colon adenocarcinoma (LD-MCA-38) cells beneath the liver capsule. Three weeks following injection of the tumor cells, the immune function of the NPCs was studied. The NPCs from tumor-bearing mice exhibited increased cytotoxic and proliferative activity. The NPCs from tumor-bearing mice also contained a greater percentage of CD8⁺ and T-cell receptor /⁺ liver-associated T lymphocytes. Levels of interleukin 6 and tumor necrosis factor were increased in the NPC supernatant, and interleukin 6 levels were increased in serum from tumor-bearing mice. We conclude that the presence of a single hepatic focus of metastatic tumor results in augmented immune function of murine liver NPCs.

(Arch Surg. 1992;127:1325-1329)

Author Affiliations
From the Departments of Surgery (Drs Johnkoski and Doerr) and Medicine (Dr Cohen), State University of New York, Buffalo, and the Department of Medicine, Duke University, Durham, NC (Dr Tzung).

Footnotes
Accepted for publication July 9, 1992.

Presented at the 45th Annual Cancer Symposium of the Society of Surgical Oncology, New York, NY, March 17, 1992.

Reprint requests to 100 High St, Buffalo, NY 14203 (Dr Doerr).

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