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Prognostic Factors in Node-Negative Breast Cancer
Houston Johnson, Jr, MD;
Shahla Masood, MD;
Claudio Belluco, MD;
Abdel-Moneim Abou-Azama, MD;
Supranee Dee, MD;
Leonard Kahn, MD;
Leslie Wise, MD
Arch Surg. 1992;127(12):1386-1391.
Abstract
• One hundred patients with node-negative breast cancer were examined to analyze the influence of tumor size, nuclear grade, and DNA content determined by flow cytometry on overall survival. Patients with diploid cancers lived significantly longer than those with aneuploid cancers (126±8 vs 80±11 months). Patients with an S-phase fraction less than 10% lived significantly longer than those with S-phase fractions 10% or greater (122±8 vs 85±10 months). Tumor size had the major impact on survival, and multivariate analysis of variance by the Cox proportional hazards model showed the greatest effect on prognosis. Tumor grade did not significantly influence overall survival.
(Arch Surg. 1992;127:1386-1391)
Author Affiliations
From the Departments of Surgery (Drs Johnson, Belluco, and Wise) and Pathology (Drs Abou-Azama and Kahn), Long Island Jewish Medical Center, New Hyde Park, NY, and Albert Einstein College of Medicine, Bronx, NY, and the Department of Pathology, University Hospital Medical Center/University of Florida Health Science Center, Jacksonville (Drs Masood and Dee).
Footnotes
Accepted for publication July 17, 1992.
Presented at the 45th Annual Cancer Symposium of the Society of Surgical Oncology, New York, NY, March 16, 1992.
Reprints not available.
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