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Michele A. Gadd, MD; Daniel G. Coit, MD

Arch Surg. 1992;127(12):1412-1416.

Abstract
• Patterns of recurrence and outcome were determined in 403 patients with melanoma who underwent an axillary or inguinal lymphadenectomy. Recurrences developed at single sites in 291 (72%) patients, with a median survival of 11 months, and at multiple sites in 112 (28%) patients, with a median survival of 3 months. Among patients with single-site recurrence, those with nonvisceral recurrence (n=190) had a median survival of 18.5 months compared with 6 months in those with visceral recurrence (n=101). Recurrences were treated surgically in 240 (60%) patients, with a median survival of 15 months, and nonsurgically in 112 patients, with a median survival of 4 months. Median survival after complete resection of single-site recurrence was 19 months compared with 6 months after incomplete resection. Multivariate analysis revealed that outcome was improved by surgical treatment, single-site and nonvisceral recurrence, and primary site in an extremity. These observations support an approach of selective resection in the treatment of recurrences after lymphadenectomy.

(Arch Surg. 1992;127:1412-1416)

Author Affiliations
From the Memorial Sloan-Kettering Cancer Center, New York, NY.

Footnotes
Accepted for publication August 8, 1992.

Presented at the 45th Annual Cancer Symposium of the Society of Surgical Oncology, New York, NY, March 17, 1992.

Reprint requests to Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY 10021 (Dr Coit).

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