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An 11-Year Experience With Patients With Burn Injury

Manu H. Desai, MD; Randi L. Rutan, RN, BSN; John P. Heggers, PhD; David N. Herndon, MD

Arch Surg. 1992;127(2):159-162.

Abstract
• The incidence of opportunistic infections after thermal injury is high. Since 1985, we have been practicing Candida prophylaxis using nystatin "swish-and-swallow" and topical therapy. Patients treated between 1980 and 1984 served as controls and received no Candida prophylaxis. Although mean burn size, full-thickness injury, and age were comparable, the incidence of Candida colonization (26.7% vs 15.6%), infection (21.3% vs 10.0%), and sepsis (12.2% vs none) was significantly different between control and nystatin-treated groups, respectively. With prophylaxis, the incidence of Candida wound infection has been significantly reduced, and systemic candidiasis has been eradicated, eliminating the need for toxic systemic antifungal agents.

(Arch Surg. 1992;127:159-162)

Author Affiliations
From the Shriners Burns Institute—Galveston (Drs Desai, Heggers, and Herndon and Ms Rutan), and the University of Texas Medical Branch, Galveston (Drs Desai, Heggers, and Herndon).

Footnotes
Accepted for publication October 12, 1991.

Presented at the 11th Annual Meeting of the Surgical Infection Society, Fort Lauderdale, Fla, April 8, 1991.

Reprint requests to Shriners Burns Institute, 610 Texas Ave, Galveston, TX 77550 (Dr Desai).

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