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Remi P. Schneider, MD; Nicolas V. Christou, MD, PhD; Carl Nohr, MD, PhD

Arch Surg. 1992;127(2):198-205.

Abstract
• Blood mononuclear cells from surgical patients produce large amounts of IgG in vitro. This synthesis is not increased by stimulation with pokeweed mitogen. To determine if this abnormal pattern of IgG synthesis extended to other immunoglobulin classes, surgical patients were stratified according to delayed-type hypersensitivity responses as reactive or anergic. Healthy personnel were studied as controls. Mononuclear cells were cultured without or with pokeweed mitogen, and IgG, IgM, and IgA were measured in supernatants. Unstimulated IgG and IgA synthesis was increased in surgical patients, especially in those with reduced delayed-type hypersensitivity responses. Synthesis of IgM was normal or low. With mitogen stimulation, IgG synthesis was increased in control and reactive subjects, but not in anergic subjects. For IgM, mitogen stimulation increased synthesis to a less than normal level in all patients. For IgA, synthesis was increased in all groups.

(Arch Surg. 1992;127:198-205)

Author Affiliations
From the Department of Surgery, Royal Victoria Hospital, and McGill University, Montreal, Quebec. Dr Schneider is now with the Department of Surgery, Vaudois University Hospital, Lausanne, Switzerland.

Footnotes
Accepted for publication November 2, 1991.

Presented at the 11th Annual Meeting of the Surgical Infection Society, Fort Lauderdale, Fla, April 10, 1991.

Reprint requests to Royal Victoria Hospital, Room R2-52,687 Pine Ave W, Montreal, Quebec, Canada H3A 1A1 (Dr Nohr).

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