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Miguel Herrera, MD; Clive Grant, MD; Jon A. van Heerden, MD; Lorraine A. Fitzpatrick, MD

Arch Surg. 1992;127(7):825-830.

Abstract
• Although rare following initial cervical exploration, reoperative parathyroid surgery may cause permanent hypoparathyroidism in 15% to 30% of patients. Immediate fresh or delayed cryopreserved parathyroid autotransplantation is the principal surgical option to resolve this complication. Between 1980 and 1990, 18 and 12 patients underwent immediate and cryopreserved autotransplantation, respectively. With a mean follow-up of nearly 5 years, 61% of the immediate and 42% of the cryopreserved tissue showed evidence of function. However, only 10 (55%) and two (17%) of the respective patients had completely discontinued treatment with calcium supplementation. Graft-dependent hypercalcemia can occur with either technique. We conclude that until cryopreserved tissue can be transplanted with more reliable success and if the excised abnormal parathyroid likely represents the only remaining gland, we would advise immediate autotransplantation. In the reoperative setting, unless a residual normal parathyroid gland is confirmed, a portion of the excised parathyroid tissue should be cryopreserved for possible autotransplantation in case hypoparathyroidism develops subsequently.

(Arch Surg. 1992;127:825-830)

Author Affiliations
From the Department of Surgery (Drs Herrera, Grant, and van Heerden) and the Division of Endocrinology (Dr Fitzpatrick), Mayo Clinic and Mayo Foundation, Rochester, Minn.

Footnotes
Accepted for publication March 21, 1992.

Presented at the 99th Scientific Session of the Western Surgical Association, Colorado Springs, Colo, November 20, 1991.

Reprint requests to Mayo Clinic and Mayo Foundation, 200 First Street SW, Rochester, MN 55905 (Dr Grant).

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