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George I. Salti, MD; Ihor Fedorak, MD; Tohru Yashiro, MD; Noreen Fulton; Hisato Hara, MD; David Yousefzadeh, MD, PhD; Edwin L. Kaplan, MD

Arch Surg. 1992;127(7):831-837.

Abstract
• During the past several decades the operation for primary hyperparathyroidism at The University of Chicago, Ill, has changed from subtotal parathyroidectomy for all patients to removal of an adenoma with performance of biopsies of all other glands to bilateral neck exploration, resection of the adenoma, and performance of fewer biopsies of normal glands. During the 1980s, 308 operations were performed; 288 patients underwent first operations. Two hundred forty-five (85.1%) of these patients had an adenoma and forty-three (14.9%) had hyperplasia (multiglandular disease); none had a carcinoma. Resolution of hypercalcemia was achieved in 281 patients (97.5%); seven patients experienced failed explorations. The early cure was the same whether or not preoperative localization studies were performed. Nineteen patients underwent 20 reoperative parathyroidectomies during this period. Preoperative localization studies, done in 16 (80%) of 20 cases, were very helpful. Ninety percent of patients with abnormal parathyroid glands in their neck or mediastinum were cured with their initial reoperation.

(Arch Surg. 1992;127:831-837)

Author Affiliations
From the Department of Surgery and Radiology, The University of Chicago (Ill) Pritzker School of Medicine. Dr Fedorak is now with Loyola University Medical Center, Maywood, Ill.

Footnotes
Accepted for publication February 2, 1992.

Presented at the 99th Scientific Session of the Western Surgical Association, Colorado Springs, Colo, November 20, 1991.

Reprint requests to the Department of Surgery and Radiology, The University of Chicago Hospitals, 5841 S Maryland Ave, MC 5031, Chicago, IL 60637 (Dr Kaplan).

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