This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

K. Fon Huang, MD; Dai H. Chung, MD; David N. Herndon, MD

Arch Surg. 1993;128(1):47-54.

Abstract
• Bacterial translocation after severe burns is associated with gut mucosal atrophy and increased mucosal permeability. Insulinlike growth factor 1 (IGF-1) levels are low after trauma and do not respond to growth hormone treatment. Since IGF-1 receptors have been demonstrated in gut mucosa, we proposed that treatment with IGF-1 would reduce mucosal atrophy and bacterial translocation. Rats received 50% total body surface area full-thickness burn or sham burn. They were treated with a continuous, subcutaneous infusion of either IGF-1 (3 mg/kg per day) or placebo (0.01 mol of acetate) for up to 5 days after receiving the burn. The mesenteric lymph node and liver were cultured for gram-negative bacteria. The small intestinal mucosa was scraped, weighed, and analyzed for DNA and protein content. Treatment with IGF-1 improved body weight, spleen weight, and gut mucosal weight. It stimulated mucosal DNA and protein content and reduced the incidence of bacterial translocation to the mesenteric lymph node from 89% to 30%. Insulinlike growth factor may reduce gut barrier failure by decreasing mucosal atrophy and subsequent barrier failure. In addition to its general anabolic effects, recombinant human IGF-1 may improve gut mucosal function and reduce infectious morbidity in severely traumatized or septic patients by reducing gut atrophy and reducing bacterial translocation.

(Arch Surg. 1993;128:47-54)

Author Affiliations
From Shriners Burns Institute and Department of Surgery, The University of Texas Medical Branch, Galveston.

Footnotes
Accepted for publication July 25, 1992.

Presented at the 12th Annual Meeting of the Surgical Infection Society, Los Angeles, Calif, April 10, 1992.

Reprint requests to Shriners Burns Institute, 815 Market St, Galveston, TX 77555 (Dr Herndon).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Gut Mucosal Homeostasis and Cellular Mediators after Severe Thermal Trauma and the Effect of Insulin-Like Growth Factor-I in Combination with Insulin-Like Growth Factor Binding Protein-3
Jeschke et al.
Endocrinology 2007;148:354-362.
ABSTRACT | FULL TEXT  

Insulin-like growth factor I improves intestinal barrier function in cirrhotic rats
Lorenzo-Zuniga et al.
Gut 2006;55:1306-1312.
ABSTRACT | FULL TEXT  

Reductions in circulating anabolic hormones induced by sustained sleep deprivation in rats
Everson and Crowley
Am. J. Physiol. Endocrinol. Metab. 2004;286:E1060-E1070.
ABSTRACT | FULL TEXT  

Insulin-like growth factor-I: a traffic control device on the road to tissue recovery
Elsasser
Am. J. Physiol. Regul. Integr. Comp. Physiol. 2003;285:R722-R723.
FULL TEXT  

IGF-I gene transfer effects on inflammatory elements present after thermal trauma
Dasu et al.
Am. J. Physiol. Regul. Integr. Comp. Physiol. 2003;285:R741-R746.
ABSTRACT | FULL TEXT  

Effect of Multiple Gene Transfers of Insulinlike Growth Factor I Complementary DNA Gene Constructs in Rats After Thermal Injury
Jeschke et al.
Arch Surg 1999;134:1137-1141.
ABSTRACT | FULL TEXT  

Effect of IGF-1 on Protein Metabolism in Burned Rats
Tashiro et al.
JPEN J Parenter Enteral Nutr 1999;23:S93-S97.
ABSTRACT  

A thermal injury-induced circulating factor(s) compromises intestinal cell morphology, proliferation, and migration
Varedi et al.
Am. J. Physiol. Gastrointest. Liver Physiol. 1999;277:G175-G182.
ABSTRACT | FULL TEXT  

Endotoxin-induced changes in IGF-I differ in rats provided enteral vs. parenteral nutrition
Wojnar et al.
Am. J. Physiol. Endocrinol. Metab. 1999;276:E455-E464.
ABSTRACT | FULL TEXT  

Effect of insulin-like growth factor I on in vivo intestinal absorption of D-galactose in cirrhotic rats
Castilla-Cortazar et al.
Am. J. Physiol. Gastrointest. Liver Physiol. 1999;276:G37-G42.
ABSTRACT | FULL TEXT  

Hepatic production and intestinal uptake of IGF-I: response to infection
Lang et al.
Am. J. Physiol. Gastrointest. Liver Physiol. 1998;275:G1291-G1298.
ABSTRACT | FULL TEXT  

Treatment of burned rats with insulin-like growth factor I inhibits the catabolic response in skeletal muscle
Fang et al.
Am. J. Physiol. Regul. Integr. Comp. Physiol. 1998;275:R1091-R1098.
ABSTRACT | FULL TEXT  

Increased protein synthesis after acute IGF-I or insulin infusion is localized to muscle in mice
Bark et al.
Am. J. Physiol. Endocrinol. Metab. 1998;275:E118-E123.
ABSTRACT | FULL TEXT  

The Anabolic Effects of IGF-1 in Skeletal Muscle After Burn Injury Are not Caused by Increased Cell Volume
Fang et al.
JPEN J Parenter Enteral Nutr 1998;22:115-119.
ABSTRACT  

Insulin-Like Growth Factor 1 Stimulates Protein Synthesis and Inhibits Protein Breakdown in Muscle From Burned Rats
Fang et al.
JPEN J Parenter Enteral Nutr 1997;21:245-251.
ABSTRACT  

The Somatogenic Hormones and Insulin-Like Growth Factor-1: Stimulators of Lymphopoiesis and Immune Function
Clark
Endocr. Rev. 1997;18:157-179.
ABSTRACT | FULL TEXT  

Insulin-Like Growth Factor 1 Has Beneficial Effects, Whereas Growth Hormone Has Limited Effects on Postoperative Protein Metabolism, Gut Integrity, and Splenic Weight in Rats With Chronic Mild Liver Injury
Inaba et al.
JPEN J Parenter Enteral Nutr 1997;21:55-62.
ABSTRACT  

Effects of Growth Hormone and Insulin-Like Growth Factor 1 (IGF-1) Treatments on the Nitrogen Metabolism and Hepatic IGF-1-Messenger RNA Expression in Postoperative Parenterally Fed Rats
Inaba et al.
JPEN J Parenter Enteral Nutr 1996;20:325-331.
ABSTRACT  

Insulin-Like Growth Factor-I Enhances Immune Response in Dexamethasone-Treated or Surgically Stressed Rats Maintained With Total Parenteral Nutrition
Hinton et al.
JPEN J Parenter Enteral Nutr 1995;19:444-452.
ABSTRACT  

Insulin-like Growth Factor-I Prevents Gut Atrophy and Maintains Intestinal Integrity in Septic Rats
Chen et al.
JPEN J Parenter Enteral Nutr 1995;19:119-124.
ABSTRACT