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Molecular Mechanisms of Resistance to Tamoxifen Therapy in Breast Cancer
Monica Morrow, MD;
V. Craig Jordan, PhD, DSc
Arch Surg. 1993;128(11):1187-1191.
Abstract
Clinical data suggest that the use of adjuvant tamoxifen citrate (Nolvadex) for a minimum of 5 years, and possibly indefinitely, will result in maximal antitumor benefit. There is concern that long-term tamoxifen maintenance therapy may result in the induction of drug resistance. This article reviews the potential molecular mechanisms of resistance to tamoxifen and explores the possibility of tamoxifen-stimulated tumor growth.
(Arch Surg. 1993;128:1187-1191)
Author Affiliations
From the Department of Surgery, University of Chicago (Ill) (Dr Morrow), and the Departments of Human Oncology and Pharmacology, University of Wisconsin, Madison (Dr Jordan). Dr Morrow is now with the Department of Surgery, Northwestern University, Chicago.
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