Cardiac Preconditioning: Induction of Endogenous Tolerance to Ischemia-Reperfusion Injury

doi:10.1001/archsurg.1993.01420230036005

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Vol. 128 No. 11, November 1993

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Cardiac Preconditioning

Induction of Endogenous Tolerance to Ischemia-Reperfusion Injury

Daniel R. Meldrum, MD; Max B. Mitchell, MD; Anirban Banerjee, PhD; Alden H. Harken, MD

Arch Surg. 1993;128(11):1208-1211.

Abstract

Cardiac preconditioning is a phenomenon by which a brief exposureto ischemia renders the heart more tolerant of a subsequentsustained ischemic insult. Understanding the mechanism involvedmay allow pharmacologic access to this protective state beforecardiopulmonary bypass surgery and transplantation. We discussherein the preconditioning phenomenon, the potential mechanismsinvolved, and the therapeutic implications of cardiac preconditioning.

(Arch Surg. 1993;128:1208-1211)

Author Affiliations

From the Department of Surgery, University of Colorado Health Sciences Center, Denver.

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