This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on Web of Science (12)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Dympna M. Kelly, MCh; Gerard P. McEntee, MCh; Kevin F. McGeeney, MSc; John M. Fitzpatrick, MCh

Arch Surg. 1993;128(3):293-295.

Abstract
• Edematous pancreatitis was induced in 12 male Sprague-Dawley rats using supramaximal doses of the cholecystokinin analogue cerulein (5 µg/kg per hour). The microvasculature of the pancreas, liver, and kidney was examined using scanning electron microscopy of microvascular corrosion casts in 12 test animals and four controls at intervals of 30 minutes, 1 hour, 2 hours, and 4 hours. Distortion of the pancreatic and hepatic microvasculature was seen as early as 30 minutes and progressed during the study period. The renal vasculature remained normal throughout. Light microscopic analysis revealed no morphologic abnormalities in the walls of the pancreatic, hepatic, or renal microvasculature. This study demonstrates that cerulein-induced pancreatitis is associated with marked distortion of the pancreatic and hepatic microvasculature; the abnormalities start early in the disease and progress during the study period.

(Arch Surg. 1993;128:293-295)

Author Affiliations
From the Department of Surgery, Mater Misericordiae Hospital (Drs Kelly, McEntee, and Fitzpatrick), and the Department of Medicine and Therapeutics, University College Dublin (Dr McGeeney), Ireland.

Footnotes
Accepted for publication May 16, 1992.

Reprint requests to the Department of Surgery, Mater Misericordiae Hospital, 47 Eccles St, Dublin 7, Ireland (Dr Fitzpatrick).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?