 |
|
Administration of Dehydroepiandrosterone to Burned Mice Preserves Normal Immunologic Competence
Barbara A. Araneo, PhD;
Jane Shelby, PhD;
Gang-Zhou Li, MD;
Wenwei Ku, MS;
Raymond A. Daynes, PhD
Arch Surg. 1993;128(3):318-325.
Abstract
• Burned individuals display a reduced ability to elicit cellular and humoral immune responses and a depression in the in vitro production of certain T-cell lymphokines. Treatment of burned mice with 100 µg of dehydroepiandrosterone within 1 hour after injury resulted in preserving a completely normal capacity to produce T-cell—derived lymphokines and to generate cellular immune responses. In addition, dehydroepiandrosterone-treated thermally injured mice demonstrated an above-normal ability to resist an induced infection with the intracellular pathogen, Listeria monocytogenes. Dehydroepiandrosterone-treated animals also did not exhibit the sustained plasma levels of interleukin 6 that normally accompany thermal injury and infection. Because of its antiglucocorticoid effects and positive immunoregulatory influences, we believe dehydroepiandrosterone to be a beneficial form of therapy for thermally injured individuals.
(Arch Surg. 1993;128:318-325)
Author Affiliations
From the Division of Cell Biology and Immunology (Drs Araneo, Li, and Daynes) and the Department of Surgery (Dr Shelby and Mr Ku), University of Utah School of Medicine, Salt Lake City.
Footnotes
Accepted for publication May 23, 1992.
Reprint requests to Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT 84132 (Dr Araneo).
 CiteULike  Connotea  Delicious  Digg  Facebook  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
An Evaluation of the Neuroendocrine Response to Sleep in Pediatric Burn Patients
Gottschlich et al.
JPEN J Parenter Enteral Nutr 2009;33:317-326.
ABSTRACT
| FULL TEXT
Immunomodulatory effects of dehydroepiandrosterone in proestrus female mice after trauma-hemorrhage
Knoferl et al.
J. Appl. Physiol. 2003;95:529-535.
ABSTRACT
| FULL TEXT
Review: Endotoxin and the hypothalamo-pituitary-adrenal (HPA) axis
Beishuizen and Thijs
Innate Immunity 2003;9:3-24.
ABSTRACT
Dehydroepiandrosterone: An Inexpensive Steroid Hormone That Decreases the Mortality Due to Sepsis Following Trauma-Induced Hemorrhage
Angele et al.
Arch Surg 1998;133:1281-1288.
ABSTRACT
| FULL TEXT
Testosterone Receptor Blockade After Hemorrhage in Males: Restoration of the Depressed Immune Functions and Improved Survival Following Subsequent Sepsis
Angele et al.
Arch Surg 1997;132:1207-1214.
ABSTRACT
|
