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Andreas G. Tzakis, MD; Jorge Reyes, MD; Konstantinos Tepetes, MD; Vangelos Tzoracoleftherakis, MD; Satoru Todo, MD; Thomas E. Starzl, MD, PhD

Arch Surg. 1993;128(3):337-339.

Abstract
• Twenty-three children with Alagille's syndrome and end-stage liver disease underwent liver transplantation with cyclosporine and low-dose steroid immunosuppression. Two to 9 years (mean, 4.4 years) after surgery, 13 (57%) of the children were still alive, with normal liver function. Three of the fatalities were due to cardiovascular failure secondary to associated cardiopulmonary disease. Mortality was higher among patients who had more severe cardiac disease and patients who had previously undergone a Kasai procedure. Although it has a higher than average risk, liver transplantation can be efficacious in patients with Alagille's syndrome and end-stage liver disease.

(Arch Surg. 1993;128:337-339)

Author Affiliations
From the Department of Surgery, University Health Center of Pittsburgh (Pa), University of Pittsburgh (Drs Tzakis, Reyes, Tepetes, Tzoracoleftherakis, Todo, and Starzl), and the Veterans Affairs Medical Center, Pittsburgh (Dr Starzl).

Footnotes
Accepted for publication June 6, 1992.

Reprint requests to the Department of Surgery, University of Pittsburgh, 3601 Fifth Ave, Pittsburgh, PA 15213 (Dr Starzl).

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