This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

William V. Kastrinakis, MD; Nirasha Ramchurren, PhD; Melinda Maggard, MD; Glenn Steele, Jr, MD, PhD; Ian C. Summerhayes, PhD

Arch Surg. 1995;130(1):9-14.

Abstract
Objective
To establish whether specific K-ras alterations are predictive of less aggressive tumor behavior and subsequently those patients who are most likely to benefit from resection of hepatic metastases from colorectal carcinoma.

Design
Evaluation of long-term survivors of hepatic resection for metastases of colorectal carcinoma (median survival, 85 months).

Results
DNA, extracted from 26 paraffin-embedded hepatic metastases from 19 patients, was analyzed using single-strand conformation polymorphism and direct sequence analysis of codons 12 and 13 of the K-ras gene. Seven of 19 patients were found to harbor K-ras mutations. A similar frequency and spectrum of K-ras mutational events was detected in 14 patients with short-term survival following pathologic diagnosis of hepatic metastasis.

Conclusions
Neither the presence of a K-ras mutational event nor the precise nucleotide change are predictive of less aggressive tumor behavior, and genetic alterations at this locus alone cannot be used to select patients undergoing resection of hepatic metastases from colorectal carcinoma.

(Arch Surg. 1995;130:9-14)

Author Affiliations
From the Laboratory of Cancer Biology, Department of Surgery, Deaconess Hospital and Harvard Medical School, Boston, Mass.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

KRAS wild-type state predicts survival and is associated to early radiological response in metastatic colorectal cancer treated with cetuximab
De Roock et al.
Ann Oncol 2008;19:508-515.
ABSTRACT | FULL TEXT  

Fractional Genomic Alteration Detected by Array-Based Comparative Genomic Hybridization Independently Predicts Survival after Hepatic Resection for Metastatic Colorectal Cancer
Mehta et al.
Clin. Cancer Res. 2005;11:1791-1797.
ABSTRACT | FULL TEXT  

Differences in KRAS Mutation Spectrum in Lung Cancer Cases between African Americans and Caucasians after Occupational or Environmental Exposure to Known Carcinogens
Hunt et al.
Cancer Epidemiol. Biomarkers Prev. 2002;11:1405-1412.
ABSTRACT | FULL TEXT  

What we could do now: molecular pathology of colorectal cancer
Houlston
Mol. Pathol. 2001;54:206-214.
ABSTRACT | FULL TEXT  

K-ras mutations in patients with early colorectal cancers
Andreyev et al.
Gut 1997;41:323-329.
ABSTRACT | FULL TEXT