Efficacy of a Fibrin Hemostatic Bandage in Controlling Hemorrhage From Experimental Arterial Injuries
CPT Michael J. Larson, VC;
LTC Jon C. Bowersox, MC;
COL Robert C. Lim, Jr, MC;
COL John R. Hess, MC
Arch Surg. 1995;130(4):420-422.
Abstract
Objective
To determine if a pressure dressing containing fibrinogen and thrombin could provide more effective control of arterial hemorrhage than a pressure dressing alone in an animal model of arterial injury.
Design
Randomized acute (nonsurvival) experiment in swine.
Setting
Federal biomedical research institute.
Animals
Six anesthetized Yorkshire swine.
Interventions
Uncontrolled arterial hemorrhage was induced in anesthetized swine by creating femoral artery lacerations. Hemorrhage was controlled by a gauze bandage containing fibrinogen and thrombin, applied with 1 minute of 3.5-kg pressure. The dressings were left in place for 1 hour after the pressure was removed. The contralateral limbs received identical treatment with plain gauze dressings.
Main Outcome Measures
Total blood loss, mean arterial pressure, and mortality were measured after 1 hour.
Results
After 1 hour, blood loss in the fibrin bandage group was 123±48 mL, compared with 734±134 mL in the control group (P=.0022). In the group treated with the fibrin bandages, there was no significant decrease in the mean arterial pressure after arterial laceration. In contrast, there was a decrease of 30 mm Hg in the group treated with gauze dressings alone. There was no animal mortality during the study period.
Conclusions
Bandages containing fibrinogen and thrombin significantly reduced the amount of blood loss and allowed mean arterial pressures to be maintained in animals with uncontrolled hemorrhage from femoral artery lacerations. A hemostatic bandage may be an important adjuvant for controlling severe extremity hemorrhage in the prehospital setting.
(Arch Surg. 1995;130:420-422)
Author Affiliations
USA; USA; USAR; USA
From the Letterman Army Institute of Research, Presidio of San Francisco, Calif (Drs Larson, Bowersox, Lim, and Hess), and the Department of Surgery, University of California, San Francisco (Drs Bowersox and Lim). Dr Bowersox is currently affliated with the Madigan Army Medical Center (HSHV-STV), Tacoma, Wash.
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