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Marco G. Patti, MD; Carlos A. Pellegrini, MD; Massimo Arcerito, MD; Jenny Tong, MD; Sean J. Mulvihill, MD; Lawrence W. Way, MD

Arch Surg. 1995;130(6):609-616.

Abstract
Objective
To compare medical with minimally invasive surgical therapy in the treatment of primary esophageal motility disorders.

Design
Prospective study.

Setting
University-based tertiary care center.

Patients
Eighty-nine patients (46 men and 43 women) with either achalasia or nutcracker esophagus and diffuse esophageal spasm (DES). Choice of treatment was based not on randomization but on the preference of the referring physician, the patient's choice, and/or the patient's eligibility to access the University of California, San Francisco, for treatment.

Interventions
Nineteen patients with achalasia and 30 patients with nutcracker esophagus and DES were treated with dilatations and/or medications. Thirty patients with achalasia and 10 with nutcracker esophagus and DES underwent a thoracoscopic myotomy.

Main Outcome Measures
Dysphagia, pain, and overall quality of life.

Results
In the surgical group, 80% of the patients with nutcracker esophagus and DES and 87% of the patients with achalasia had good or excellent results. In contrast, in the medical group, 26% of the patients with nutcracker esophagus and DES and 26% of the patients with achalasia had good or excellent results.

Conclusions
Surgery by minimally invasive techniques offers a better chance than does medical therapy or dilatation of rendering the patient with achalasia, nutcracker esophagus, and DES asymptomatic.

(Arch Surg. 1995;130:609-616)

Author Affiliations
From the Department of Surgery, University of California, San Francisco. Dr Pellegrini is presently at the Department of Surgery, the University of Washington, Seattle.

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