You are seeing this message because your Web browser does not support basic Web standards. Find out more about why this message is appearing and what you can do to make your experience on this site better.


ABOUT ARCHIVES
Advanced Search

Welcome   | My Account | E-mail Alerts | Access Rights | Sign In


  Vol. 131 No. 1, January 1996 TABLE OF CONTENTS
  Archives
  •  Online Features
  Original Articles
 This Article
 •References
 •Full text PDF
 •Send to a friend
 • Save in My Folder
 •Save to citation manager
 •Permissions
 Citing Articles
 •Citation map
 •Citing articles on HighWire
 •Citing articles on Web of Science (14)
 •Contact me when this article is cited
 Related Content
 •Similar articles in this journal
 Social Bookmarking
  Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit Add to Technorati Add to Twitter What's this?

Expression of p53 Protein in Colorectal Carcinoids

Jhy-Young Cheng, MD, PhD; Lai-Fa Sheu, MD; Ching-Liang Meng, MD, PhD; Jih-Chang Lin, MD

Arch Surg. 1996;131(1):67-70.


Abstract

Objective
To determine the frequency and prognostic significance of p53 protein expression in colorectal carcinoid tumors.

Design
Thirty-one paraffin-embedded specimens of colorectal carcinoid tumor were studied by immunohistochemical staining to detect p53 protein expression. The association of p53 expression with tumor site, tumor size, invasion level, tumor stage, DNA pattern, and patient survival were analyzed.

Results
p53 protein was detected in five (16%) of 31 colorectal carcinoid tumors. There was a correlation between p53 overexpression and tumor site, tumor size, tumor stage, and DNA ploidy (P<.05) but not for the depth of tumor invasion (P=.06). In addition to tumor size, invasion, stage, and DNA aneuploidy, p53 protein overexpression was also indicative of a poor prognosis (P<.001).

Conclusions
The overexpression of p53 protein is uncommon in colorectal carcinoid tumors. However, the expression of p53 protein has a correlation with clinicopathologic-predicting criteria in colorectal carcinoid tumors and may be used as an associated prognostic parameter to assess patient survival.

(Arch Surg. 1996;131:67-70)



Author Affiliations

From the Division of Colon and Rectal Surgery, Departments of Surgery (Drs Cheng and Lin), Pathology (Dr Sheu), and Medical Research (Dr Meng), Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.



Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Loss of Nuclear p27 Expression and Its Prognostic Role in Relation to Cyclin E and p53 Mutation in Gastroenteropancreatic Neuroendocrine Tumors
Grabowski et al.
Clin. Cancer Res. 2008;14:7378-7384.
ABSTRACT | FULL TEXT  

Gastrin releasing peptide and gastrin releasing peptide receptor expression in gastrointestinal carcinoid tumours
Scott et al.
J. Clin. Pathol. 2004;57:189-192.
ABSTRACT | FULL TEXT  





HOME | CURRENT ISSUE | PAST ISSUES | TOPIC COLLECTIONS | CME | SUBMIT | SUBSCRIBE | HELP
CONDITIONS OF USE | PRIVACY POLICY | CONTACT US | SITE MAP
 
© 1996 American Medical Association. All Rights Reserved.