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John T. Owings, MD; F. William Blaisdell, MD

Arch Surg. 1996;131(10):1069-1073.

Abstract
Objective
To determine a rational approach to heparin dosing for thromboembolism prophylaxis.

Design
Literature review.

Results
Three commonly used heparin dosing regimens were identified: (1) standard low-dose heparin (5000 U administered subcutaneously 2-3 times per day); (2) adjusted-dose heparin (adequate to elevate the activated partial thromboplastin time to 5 seconds above the upper limit of normal); and (3) low-molecular-weight heparin (30 mg subcutaneously twice daily without monitoring).

Conclusions
Adjusted-dose heparin thromboembolism prophylaxis is both the safest and most reliable method currently available.

Arch Surg. 1996;131:1069-1073

Author Affiliations
From the Department of Surgery, University of California, Davis, Medical Center, Sacramento, Calif.

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