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Richard L. Jamison, MD; John H. Donohue, MD; David M. Nagorney, MD; Charles B. Rosen, MD; W. Scott Harmsen, MS; Duane M. Ilstrup, MS

Arch Surg. 1997;132(5):505-511.

Abstract
Objectives
To determine the long-term disease-free and overall survivals for patients undergoing hepatic resection for colorectal cancer metastases and to define significant predictors of improved patient survival.

Design
Retrospective review.

Setting
Single tertiary care center.

Patients
Two hundred eighty consecutive patients underwent hepatic resection for colorectal cancer metastases at the Mayo Clinic from 1960 to 1987. Fifty patients alive at the completion of the study had a mean follow-up of 11.3 years (median, 121 months).

Main Outcome Measures
Disease-free interval following initial hepatic resection and death.

Results
The overall 5-year survival of the 280 patients was 27%. Twenty-eight patients were alive at 10 years from the time of hepatic resection, and the 10-year actuarial survival was 20%. Only 2 patients alive and free of disease at 5 years had recurrent disease. For all other patients who were free of disease more than 5 years after hepatic resection and died, the cause of death was not cancer related. No patient characteristics or features of the primary tumor affected survival. Clinical presentation of metastatic disease, configuration of hepatic lesions, the presence of extrahepatic lymph node involvement, and the existence of resectable extrahepatic disease significantly affected long-term patient survival. Need for perioperative blood product transfusion was associated with a lower probability of long-term survival.

Conclusion
Disease-free patient survival beyond 5 years from surgical resection of colorectal cancer metastases to the liver represents patient cure in nearly all instances.

Arch Surg. 1997;132:505-511

Author Affiliations
From the Department of Surgery (Drs Jamison, Donohue, Nagorney, and Rosen) and the Section of Biostatistics (Mr Harmsen and Mr Ilstrup), Mayo Clinic and Mayo Foundation, Rochester, Minn.

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