This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Richard L. Jamison, MD; John H. Donohue, MD; David M. Nagorney, MD; Charles B. Rosen, MD; W. Scott Harmsen, MS; Duane M. Ilstrup, MS

Arch Surg. 1997;132(5):505-511.

Abstract
Objectives
To determine the long-term disease-free and overall survivals for patients undergoing hepatic resection for colorectal cancer metastases and to define significant predictors of improved patient survival.

Design
Retrospective review.

Setting
Single tertiary care center.

Patients
Two hundred eighty consecutive patients underwent hepatic resection for colorectal cancer metastases at the Mayo Clinic from 1960 to 1987. Fifty patients alive at the completion of the study had a mean follow-up of 11.3 years (median, 121 months).

Main Outcome Measures
Disease-free interval following initial hepatic resection and death.

Results
The overall 5-year survival of the 280 patients was 27%. Twenty-eight patients were alive at 10 years from the time of hepatic resection, and the 10-year actuarial survival was 20%. Only 2 patients alive and free of disease at 5 years had recurrent disease. For all other patients who were free of disease more than 5 years after hepatic resection and died, the cause of death was not cancer related. No patient characteristics or features of the primary tumor affected survival. Clinical presentation of metastatic disease, configuration of hepatic lesions, the presence of extrahepatic lymph node involvement, and the existence of resectable extrahepatic disease significantly affected long-term patient survival. Need for perioperative blood product transfusion was associated with a lower probability of long-term survival.

Conclusion
Disease-free patient survival beyond 5 years from surgical resection of colorectal cancer metastases to the liver represents patient cure in nearly all instances.

Arch Surg. 1997;132:505-511

Author Affiliations
From the Department of Surgery (Drs Jamison, Donohue, Nagorney, and Rosen) and the Section of Biostatistics (Mr Harmsen and Mr Ilstrup), Mayo Clinic and Mayo Foundation, Rochester, Minn.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Patients With Initially Unresectable Colorectal Liver Metastases: Is There a Possibility of Cure?
Adam et al.
JCO 2009;27:1829-1835.
ABSTRACT | FULL TEXT  

Peritoneal Surface Disease from Colorectal Cancer: Comparison with the Hepatic Metastases Surgical Paradigm in Optimally Resected Patients
Shen et al.
Ann. Surg. Oncol. 2008;15:3422-3432.
ABSTRACT | FULL TEXT  

Is Hepatic Resection Justified After Chemotherapy in Patients With Colorectal Liver Metastases and Lymph Node Involvement?
Adam et al.
JCO 2008;26:3672-3680.
ABSTRACT | FULL TEXT  

Focal Liver Lesion Detection and Characterization with Diffusion-weighted MR Imaging: Comparison with Standard Breath-hold T2-weighted Imaging
Parikh et al.
Radiology 2008;246:812-822.
ABSTRACT | FULL TEXT  

Expanding Criteria for Resectability of Colorectal Liver Metastases
Pawlik et al.
The Oncologist 2008;13:51-64.
ABSTRACT | FULL TEXT  

Colorectal Liver Metastases: Treat Effectively Up Front and Consider the Borderline Resectable
Vauthey
JCO 2007;25:4524-4525.
FULL TEXT  

Actual 10-Year Survival After Resection of Colorectal Liver Metastases Defines Cure
Tomlinson et al.
JCO 2007;25:4575-4580.
ABSTRACT | FULL TEXT  

Simplified Staging System for Predicting the Prognosis of Patients With Resectable Liver Metastasis: Development and Validation
Minagawa et al.
Arch Surg 2007;142:269-276.
ABSTRACT | FULL TEXT  

Preoperative Positron Emission Tomography to Evaluate Potentially Resectable Hepatic Colorectal Metastases
Joyce et al.
Arch Surg 2006;141:1220-1226.
ABSTRACT | FULL TEXT  

Placement of a long tapered side-hole catheter in the hepatic artery: technical advantages, catheter stability, and arterial patency.
Seki and Shiina
Am. J. Roentgenol. 2006;187:1312-1320.
ABSTRACT | FULL TEXT  

Intraoperative Triple Antenna Hepatic Microwave Ablation
Simon et al.
Am. J. Roentgenol. 2006;187:W333-W340.
ABSTRACT | FULL TEXT  

Selection Criteria for Simultaneous Resection in Patients With Synchronous Liver Metastasis
Minagawa et al.
Arch Surg 2006;141:1006-1012.
ABSTRACT | FULL TEXT  

Short Time to Recurrence After Hepatic Resection Correlates with Poor Prognosis in Colorectal Hepatic Metastasis
Takahashi et al.
Jpn J Clin Oncol 2006;36:368-375.
ABSTRACT | FULL TEXT  

Hepatic and Extrahepatic Colorectal Metastases: When Resectable, Their Localization Does Not Matter, But Their Total Number Has a Prognostic Effect
Elias et al.
Ann. Surg. Oncol. 2005;12:900-909.
ABSTRACT | FULL TEXT  

Microwave Ablation: Principles and Applications
Simon et al.
RadioGraphics 2005;25:S69-S83.
ABSTRACT | FULL TEXT  

The value of residual liver volume as a predictor of hepatic dysfunction and infection after major liver resection
Schindl et al.
Gut 2005;54:289-296.
ABSTRACT | FULL TEXT  

Prognostic Scoring in Colorectal Cancer Liver Metastases: Development and Validation
Schindl et al.
Arch Surg 2005;140:183-189.
ABSTRACT | FULL TEXT  

Results of R0 Resection for Colorectal Liver Metastases Associated With Extrahepatic Disease
Elias et al.
Ann. Surg. Oncol. 2004;11:274-280.
ABSTRACT | FULL TEXT  

An Update on Hepatic Arterial Infusion Chemotherapy for Colorectal Cancer
Cohen and Kemeny
The Oncologist 2003;8:553-566.
ABSTRACT | FULL TEXT  

Patients' views on follow up of colorectal cancer: implications for risk communication and decision making
Papagrigoriadis and Heyman
Postgrad. Med. J. 2003;79:403-407.
ABSTRACT | FULL TEXT  

Feasibility of Adjuvant Hepatic Arterial Infusion of Chemotherapy After Radiofrequency Ablation With or Without Resection in Patients With Hepatic Metastases From Colorectal Cancer
Scaife et al.
Ann. Surg. Oncol. 2003;10:348-354.
ABSTRACT | FULL TEXT  

Hepatic Microwave Ablation With Multiple Antennae Results in Synergistically Larger Zones of Coagulation Necrosis
Wright et al.
Ann. Surg. Oncol. 2003;10:275-283.
ABSTRACT | FULL TEXT  

Surgery of liver metastases from colorectal cancer: new promises
Penna and Nordlinger
Br Med Bull 2002;64:127-140.
ABSTRACT | FULL TEXT  

Liver Resection for Multiple Colorectal Metastases: Influence of Parenchymal Involvement and Total Tumor Volume, vs Number or Location, on Long-term Survival
Ercolani et al.
Arch Surg 2002;137:1187-1192.
ABSTRACT | FULL TEXT  

Genetic and Histological Assessment of Surgical Margins in Resected Liver Metastases From Colorectal Carcinoma: Minimum Surgical Margins for Successful Resection
Kokudo et al.
Arch Surg 2002;137:833-840.
ABSTRACT | FULL TEXT  

Combined-Modality Treatment for Resectable Metastatic Colorectal Carcinoma to the Liver: Surgical Resection of Hepatic Metastases in Combination With Continuous Infusion of Chemotherapy--An Intergroup Study
Kemeny et al.
JCO 2002;20:1499-1505.
ABSTRACT | FULL TEXT  

The Mayo Clinic Experience With Multimodality Treatment of Locally Advanced or Recurrent Colon Cancer
Taylor et al.
Ann. Surg. Oncol. 2002;9:177-185.
ABSTRACT | FULL TEXT  

Colorectal Hepatic Metastases: Resection, Local Ablation, and Hepatic Artery Infusion Pump Are Associated With Prolonged Survival
Heslin et al.
Arch Surg 2001;136:318-323.
ABSTRACT | FULL TEXT  

Interval Hepatic Resection of Colorectal Metastases Improves Patient Selection
Lambert et al.
Arch Surg 2000;135:473-480.
ABSTRACT | FULL TEXT  

SURGICAL TREATMENT FOR BOTH PULMONARY AND HEPATIC METASTASES FROM COLORECTAL CANCER
Kobayashi et al.
J. Thorac. Cardiovasc. Surg. 1999;118:1090-1096.
ABSTRACT | FULL TEXT  

Characterization of p53 Mutations in Colorectal Liver Metastases and Correlation with Clinical Parameters
Tullo et al.
Clin. Cancer Res. 1999;5:3523-3528.
ABSTRACT | FULL TEXT  

CT-monitored Percutaneous Cryoablation in a Pig Liver Model: Pilot Study
Lee et al.
Radiology 1999;211:687-692.
ABSTRACT | FULL TEXT