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John A. Ryan, Jr, MD; Brian Eisenberg, MD; Kristi M. Pado, MD; Faye Lee, RN

Arch Surg. 1997;132(8):886-891.

Abstract
Objectives
To determine the success of unilateral exploration vs bilateral exploration for primary hyperparathyroidism and to analyze the validity of preoperative localization tests.

Design
Case-control study of patients who underwent surgical exploration (unilateral, n=43; bilateral, n=57) by 1 surgeon from January 1991 through May 1996 and who had ultrasound examination of the neck and thallium-technetium scintigraphy performed before parathyroid surgery. Initially, unilateral exploration was used sparingly, but it became the standard approach in 1994 if localization was correct.

Setting
Urban multispecialty clinic, teaching hospital.

Patients
One hundred consecutive patients who underwent surgical exploration for primary hyperparathyroidism.

Interventions
Ultrasonography of the neck, thalliumtechnetium scintigraphy, and parathyroidectomy.

Main Outcome Measures
Imaging success, operative success, and operative time.

Results
In 94 patients with solitary adenomas, the adenoma was demonstrated by ultrasound scans in 66%, by thallium-technetium scintigraphy in 83%, and by either test in 87%. Correct identification by ultrasonography was 59%; by thallium-technetium scintigraphy, 75%; and together, 73%. Of 6 patients with multiple-gland disease, 2 were correctly identified by localization tests and 9 of 15 abnormal glands were demonstrated. Of the 43 unilateral explorations, 43 single adenomas and no cases of multiple-gland disease were identified; of the 57 bilateral explorations, 51 single adenomas and 6 cases of multiple-gland disease were identified. No complications occurred in either group. Hypercalcemia persisted in 3 patients who underwent bilateral exploration and recurrent hypercalcemia developed in 1 patient in each group. The average operative time for the unilateral procedure was 105 minutes, and for the bilateral procedure, 184 minutes (P<.001). Since 1994, 31 (66%) of 47 patients have had unilateral exploration based on correct localization tests.

Conclusions
Unilateral exploration that is based on the results of localization tests requires less operative time and produces results similar to bilateral exploration.

Arch Surg. 1997;132:886-891

Author Affiliations
From the Departments of Surgery (Drs Ryan and Pado and Ms Lee) and Radiology (Dr Eisenberg), Virginia Mason Medical Center, Seattle, Wash.

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