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Wen Shen; Unal Sabanci, MD; Eugene T. Morita, MD; Allan E. Siperstein, MD; Quan-Yang Duh, MD; Orlo H. Clark, MD

Arch Surg. 1997;132(9):969-976.

Abstract
Objective
To determine whether technetium Tc 99m sestamibi scanning is accurate enough to allow surgeons to perform unilateral neck exploration for first-time parathyroidectomy in patients with primary hyperparathyroidism.

Design
Retrospective review.

Setting
University tertiary care center.

Patients
Forty patients with primary hyperparathyroidism who underwent sestamibi scanning before first-time parathyroidectomy, of whom 28 had single adenomas, 9 had multiple adenomas, and 3 had hyperplasia.

Interventions
All 40 patients underwent bilateral neck exploration with identification of 4 parathyroid glands.

Main Outcome Measures
We compared the results of preoperative sestamibi scanning with operative and histologic findings. We then used these data to calculate the projected success rates of parathyroidectomy if unilateral neck explorations had been performed based on the results of sestamibi scanning, instead of bilateral explorations.

Results
Sestamibi scanning was correct in 20 (71%) of 28 patients with single adenomas, 4 (44%) of 9 patients with multiple adenomas, and O (0%) of 3 patients with hyperplasia. If unilateral neck explorations had been performed on the basis of localization by sestamibi scanning, parathyroidectomy would have failed in 4 (10%) of 40 patients.

Conclusions
Sestamibi scanning, although helpful, is inadequate for directing unilateral neck exploration for first-time parathyroidectomy. Surgeons who perform unilateral neck exploration based on the results of sestamibi scanning will record a higher failure rate and incur higher costs than those who perform bilateral neck exploration for first-time parathyroidectomy.

Arch Surg. 1997;132:969-976

Author Affiliations
From the Departments of Surgery (Mr Shen and Drs Sabanci, Siperstein, Duh, and Clark) and Nuclear Medicine (Dr Morita), University of California—San Francisco/Mount Zion Medical Center, San Francisco, Calif.

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