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Brian D. Shames, MD; Craig H. Selzman, MD; Xianzhong Meng, MD; Daniel R. Meldrum, MD; Brian S. Cain, MD; Alden H. Harken, MD

Arch Surg. 1998;133:667-669.

It is the regulation of gene expression that determines phenotype and cellular response. Several families of proteins control gene expression in cells and influence the pathogenesis of multiple organ failure, the acute phase response, atherosclerosis, and graft-vs-host disease. Understanding the basics of the regulation of gene transcription will allow the knowledgeable surgeon to target gene expression as a therapeutic modality in multiple diseases. We examine nuclear factor kappa B as an example of a transcription factor that is involved in multiple surgical diseases and has pharmacological inhibitors available to knowledgeable surgeons.

From the Department of Surgery, University of Colorado Health Sciences Center, Denver.

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