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Transfusion Timing and Postoperative Septic Complications After Gastric Cancer Surgery
A Retrospective Study of 179 Consecutive Patients
Rocco Bellantone, MD;
Antonio Sitges-Serra, MD;
Maurizio Bossola, MD;
Giovanni Battista Doglietto, MD;
Marina Malerba, MD;
Guzman Franch, MD;
Fabio Pacelli, MD;
Francesco Crucitti, MD
Arch Surg. 1998;133:988-992.
Background Immunosuppression associated with homologous blood transfusion was first observed in renal allograft transplantation. Clinical effects of transfusion-induced immunosuppression in surgical patients have been debated in the literature for more than a decade with contradictory results.
Objective To investigate whether homologous blood transfusions significantly affect postoperative septic morbidity and mortality in patients undergoing elective surgery for gastric cancer.
Design Case series.
Setting Hospitalized care.
Patients The hospital records of 209 patients who underwent elective surgery for gastric cancer at the Department of Surgery of the Hospital del Mar, Autonomous University of Barcelona in Spain, and at the Department of Surgery of the Catholic University of Rome in Italy from April 1984 to December 1990 were reviewed, and 179 patients were included in the study.
Main Outcome Measures The following variables were entered into univariate and multivariate analyses to identify factors potentially affecting postoperative septic morbidity: demographic data, weight loss, preoperative serum albumin level and lymphocyte count, type and duration of operative procedure, amount and timing of blood transfusion, and stage of disease.
Results Univariate analysis showed that a large quantity of blood transfused (>1500 mL) and transfusion in the postoperative period (group C) were associated with a worse clinical outcome. Postoperative transfusion was an independent predictor of septic morbidity in multivariate analysis.
Conclusions Despite transfusion-induced immunomodulation, homologous blood transfusion should not be considered a risk factor for postoperative septic morbidity in patients undergoing elective major abdominal surgery. The timing-response relationship between transfusions and septic morbidity in multivariate analysis may be the effect of uncontrolled confounders such as variation of volemia induced by stress response in patients who were developing or had just developed infectious complications.
From the Istituto di Clinica Chirurgica, Università Cattolica del Sacro Cuore, Roma, Italy (Drs Bellantone, Bossola, Battista Doglietto, Malerba, Pacelli, and Crucitti); and the Department of Surgery, Hospital del Mar, Autonomous University of Barcelona, Barcelona, Spain (Drs Sitges-Serra and Franch).
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