 |
 |

Growth Hormone Attenuates Tumor Necrosis Factor in Burned Children
Minas T. Chrysopoulo, MD;
Marc G. Jeschke, MD;
Roque J. Ramirez, MD;
Robert E. Barrow, PhD;
David N. Herndon, MD
Arch Surg. 1999;134:283-286.
Background Recombinant human growth hormone (rhGH) has been shown to favorably modulate the acute-phase response and may improve the clinical outcome.
Objective To examine whether rhGH attenuates the elevated tumor necrosis factor (TNF- ) levels that correlate with increased multiorgan failure and mortality in burned adults and children.
Design Twenty children with burns of greater than 40% of the total body surface area were randomly divided into 2 groups to receive placebo (n=10) or rhGH, 0.2 mg/kg per day intramuscularly (n=10).
Setting Pediatric burn hospital.
Main Outcome Measure Serum TNF- levels by enzyme-linked immunoassay at baseline (day 0) and at 21 and 42 days after injury. For statistical analysis, we used the Kruskal-Wallis and Friedman tests.
Results No significant differences in age (mean ± SD, 6.2 ± 1.6 vs 5.0 ± 1.2 years) or percentage of total body surface area burn (mean ± SD, 65.1% ± 8.2% vs 57.1% ± 5.2%) could be shown between the groups given rhGH and placebo. Baseline TNF- levels were elevated from reference values in both groups. Twenty-one and 42 days after rhGH administration, serum TNF- levels were significantly decreased from those at baseline (P<.05). No significant decrease in TNF- levels was observed in the placebo group (P=.5).
Conclusions Recombinant human growth hormone significantly lowers serum TNF- levels after burn injury. This is consistent with the beneficial effect that rhGH has on the acute-phase response.
From the Shriners Hospitals for Children, Galveston Burns Institute and the Department of Surgery, University of Texas Medical Branch, Galveston.
CiteULike Connotea Del.icio.us Digg Reddit Technorati Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
 |
Growth hormone prevents acute liver injury induced by cardiopulmonary bypass in a rat model
An and Xiao
J. Thorac. Cardiovasc. Surg. 2007;134:342-350.
ABSTRACT
| FULL TEXT
The preventative role of growth hormone on acute liver injury induced by cardiopulmonary bypass in a rat model
An and Xiao
Eur. J. Cardiothorac. Surg. 2007;31:1037-1043.
ABSTRACT
| FULL TEXT
Endocrine Changes in Critical Illness
Nylen and Muller
J Intensive Care Med 2004;19:67-82.
ABSTRACT
Modulation of Inflammatory and Catabolic Responses in Severely Burned Children by Early Burn Wound Excision in the First 24 Hours
Barret and Herndon
Arch Surg 2003;138:127-132.
ABSTRACT
| FULL TEXT
Fitness, Training, and the Growth Hormone{->}Insulin-Like Growth Factor I Axis in Prepubertal Girls
Eliakim et al.
J. Clin. Endocrinol. Metab. 2001;86:2797-2802.
ABSTRACT
| FULL TEXT
Attenuation of the Acute-Phase Response in Thermally Injured Rats by Cholesterol-Containing Cationic Liposomes Used as a Delivery System for Gene Therapy
Jeschke et al.
Arch Surg 1999;134:1098-1102.
ABSTRACT
| FULL TEXT
|