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Ten Years' Experience

William F. Oppat, MD; William H. Pearce, MD; William D. McMillan, MD; Jon S. Matsumura, MD; Walter J. McCarthy, MD; James S. T. Yao, MD, PhD

Arch Surg. 1999;134:754-758.

Background  We previously reported 48-month patency rates of composite sequential bypass (CSB) approaching 60%. Yet, extended patency and limb salvage rates are unknown.

Hypothesis  Long-term patency and limb salvage rates of CSB are affected by sex, bypass configuration, and warfarin therapy.

Design  Medical records of all patients who underwent CSB during a 10-year period were retrospectively reviewed.

Setting  A referral center for the Chicago, Ill, region.

Patients  One hundred consecutive patients (mean age, 68.8 years; 57% were men and 49% had diabetes) undergoing 102 CSBs for limb salvage (ulcer, 43%; rest pain, 39%; and gangrene, 18%) from January 1986 to January 1996 were identified.

Interventions  Warfarin was used after surgery by 72% of patients and aspirin was used by the remainder of them.

Main Outcome Measures  Life table primary patency and limb salvage rates were compared for sex, diabetes mellitus status, location of distal prosthetic anastomosis (above knee vs below knee), and anticoagulation drug therapy (warfarin sodium vs aspirin) with log-rank statistics.

Results  Primary patency of CSB was 56% at 24 months, 29% at 48 months, and 20% at 84 months (SE<10%; mean follow-up, 19.6 months [range, 1.0-110.0 months]). Limb salvage rates were 64% at 24 months, 30% at 48 months, and 23% at 84 months (SE<10%); 66% and 90% of patients had failed grafts requiring amputation by 3 months and 1 year, respectively.

Conclusions  Composite sequential bypass for limb salvage provides reasonable 2-year patency. However, patency rates steadily declined from year 2 to year 5. After CSB failure, limb salvage rates are poor, with 90% of patients progressing to amputation within 1 year.

From the Division of Vascular Surgery, Department of Surgery, Northwestern University Medical School (Drs Oppat, Pearce, Matsumura, and Yao); and the Division of Vascular Surgery, Rush-St Luke's Medical Center (Dr McCarthy), Chicago, Ill; and Minnesota Thoracic Associates, Minneapolis (Dr McMillan).