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Daniel L. Flugstad, MD; Christian P. Wilke, MD; Michael A. McNutt, MD; Richard A. Welk, MD; Michael J. Hart, MD; William C. McQuinn, MD

Arch Surg. 1999;134:856-862.

Hypothesis  A systemic disease-free state necessitates a local disease-free state. This cannot be accomplished without a properly performed resection by an experienced surgical team. Successful local management of soft tissue sarcoma (STS) may lead to improved disease-free survival. An STS treatment protocol using wide local excision followed by radiation therapy is effective in achieving local tumor control and survival similar to that of multiple-modality regimens, but with lower morbidity.

Design  Retrospective cohort review (August 1, 1987, to May 6, 1998).

Setting  Referral to a single musculoskeletal oncologic surgeon, with surgery performed at a tertiary care medical center in a large urban area.

Patients  Ninety patients with STS of the trunk or extremities.

Interventions  Preoperative evaluation included surveillance computed tomographic scan of the chest, magnetic resonance imaging of primary site to assess tumor extent and to plan the surgical approach, and angiography if vascular bypass was proposed. Wide local excision of tumor was performed, with concomitant vascular bypass and/or complex plastic reconstruction as needed. Postoperative radiation therapy was given in most patients. Adjuvant chemotherapy was used selectively.

Main Outcome Measures  Morbidity, local recurrence rates, and survival.

Results  Histologically negative margins were obtained in 89 (99%) of 90 patients; 86 (96%) remained free of local disease at follow-up. Five patients died of systemic metastatic disease.

Conclusion  Excellent local control obtained with aggressive, appropriate surgery followed by radiation therapy in most patients and chemotherapy in only selective high-risk patients leads to excellent survival, with low morbidity and good functional outcome.

From the Departments of Orthopedic Surgery (Dr Flugstad), Surgery (Drs Wilke, Welk, Hart, and McQuinn), and Pathology (Dr McNutt), Swedish Medical Center, Seattle, Wash.

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