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Protective Covering of Surgical Wounds With Honey Impedes Tumor Implantation
 smail Hamzaoglu, MD;
Kaya Saribeyoglu, MD;
Haydar Durak, MD;
Tayfun Karahasanoglu, MD;
brahim Bayrak;
Tuncay Altug, MD;
Feridun Sirin, MD;
Muzaffer Sar yar, MD
Arch Surg. 2000;135:1414-1417.
Hypothesis Tumor implantation (TI) development at the surgical wound following cancer surgery is still an unresolved concern. Trocar site recurrence, which is likely a form of TI, has become one of the most controversial topics and, with the widespread acceptance of laparoscopic surgery, has caused renewed interest in questions about TI. Honey has positive effects on wound healing. Physiological and chemical properties of honey might prevent TI when applied locally.
Design, Interventions, and Main Outcome Measures Sixty BALB/c strain mice, divided into 2 groups, were wounded in the posterior neck area. Group 1 mice formed the control group, and group 2 mice had wounds coated with honey before and after tumor inoculation. All wounds were inoculated with transplantable Ehrlich ascites tumor. The presence of TI was confirmed in the wounded area by histopathological examination on the 10th day.
Results Tumor implantation was achieved in all group 1 animals and verified by palpable mass and histopathological examination. In group 2 mice, although TI could not be detected macroscopically, it was revealed by pathological examination in 8 cases. Tumor implantation was less likely in group 2 mice (8 of 30 vs 30 of 30; P<.001).
Conclusions Tumor implantation was markedly decreased by the application of honey pre- and postoperatively. It is possible that the physiological and chemical properties of honey protected wounds against TI. Honey could be used as a wound barrier against TI during pneumoperitoneum in laparoscopic oncological surgery and in other fields of oncological surgery.
From the Departments of Surgery (Drs Hamzaoglu, Saribeyoglu, Karahasanoglu, Sirin, and Sariyar), Pathology (Dr Durak), and Medical Biology (Mr Bayrak), and the Experimental Animal Research and Production Laboratory (Dr Altug), Cerrahpa a Medical School,  stanbul, Turkey.
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