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Jeffrey L. Seeburger, PhD; Michael Stepak, MD; Steven G. Fukuchi, MD; Jamie E. Siegel, MD; Rolando H. Rolandelli, MD

Arch Surg. 2000;135:721-722.

The most recently characterized genetic defect contributing to venous thrombophilia is the 20210 A prothrombin gene mutation. We describe a patient with this defect who had arterial thrombosis resulting in considerable mesenteric ischemia. Several environmental factors, which might otherwise be considered of low thrombotic risk, may also have contributed to her condition. The recognition of the potential for novel presentations of hypercoagulable states may contribute to a reduction in the morbidity associated with acute mesenteric ischemia.

From the Department of Surgery, MCP Hahnemann University (Drs Seeburger and Stepak), and Temple University Hospital (Drs Fukuchi and Rolandelli), Philadelphia, Pa; and the Department of Medicine, Division of Hematology, University of Medicine and Dentistry of New Jersey (Dr Siegel), New Brunswick.

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