 |
|
Anticoagulation of Children Undergoing Cardiopulmonary Bypass Is Overestimated by Current Monitoring Techniques
John T. Owings, MD;
Marc E. Pollock, MD;
Robert C. Gosselin, MT;
Kevin Ireland, RN, CCP;
Jonathan S. Jahr, MD;
Edward C. Larkin, MD
Arch Surg. 2000;135:1042-1047.
Hypothesis Children who undergo cardiopulmonary bypass (CPB) are proportionally more hemodiluted than adults who undergo CPB. Current methods of monitoring high-dose heparin sulfate anticoagulation are dependent on fibrinogen level. Because of the decreased fibrinogen levels in children, current methods of monitoring heparin anticoagulation overestimate their level of anticoagulation.
Design Prospective controlled trial.
Main Outcome Measure Production of thrombin (adequacy of anticoagulation).
Methods Children and adults undergoing cardiac surgery who received CPB were anticoagulated in the standard fashion as directed by activated clotting time (ACT) results. Each subject had blood sampled at baseline; heparinization; start of the CPB; CPB at 30, 60, and 90 minutes; and at termination of CPB. Samples were used to assess anticoagulation with the Heparin Management Test (less dependent on fibrinogen level than ACT). We also assessed 2 subclinical markers of thrombosis, thrombin-antithrombin complexes and prothrombin fragment F1.2; a marker of procoagulant reserve, fibrinogen; the natural antithrombotic, antithrombin; and heparin concentration.
Results Ten children and 10 adults completed the study. Children had lower fibrinogen levels than adults throughout CPB (P<.05). All adults had both therapeutic ACT and Heparin Management Test levels measured throughout CPB. Although children had therapeutic ACT levels, their Heparin Management Test levels were subtherapeutic while undergoing CPB. The children had significantly higher thrombin-antithrombin complexes and prothrombin fragment F1.2 than adults, indicating ongoing thrombin production (P<.01). The increases in thrombin-antithrombin complexes and prothrombin fragment F1.2 in children were inversely proportional to their weight.
Conclusions Children undergoing CPB with heparin dosing adjusted to optimize the ACT manifest inadequate anticoagulation (ongoing thrombin formation). High-dose heparin anticoagulation therapy in children undergoing CPB should be directed by tests (like the Heparin Management Test) that are less dependent on fibrinogen level than ACT.
From the Departments of Surgery (Drs Owings and Pollock and Mr Ireland), Pathology (Mr Gosselin and Dr Larkin), and Anesthesiology (Dr Jahr), University of California–Davis Health System, Sacramento, Calif. The authors have no commercial, proprietary, or financial interests in the products or companies described in this article.
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
A Comparison of Heparin Management Strategies in Infants Undergoing Cardiopulmonary Bypass
Guzzetta et al.
Anesth. Analg. 2008;106:419-425.
ABSTRACT
| FULL TEXT
Anticoagulation and Pediatric Extracorporeal Membrane Oxygenation: Impact of Activated Clotting Time and Heparin Dose on Survival
Baird et al.
Ann. Thorac. Surg. 2007;83:912-920.
ABSTRACT
| FULL TEXT
Factors Influencing Neurologic Outcome After Neonatal Cardiopulmonary Bypass: What We Can and Cannot Control
Hsia and Gruber
Ann. Thorac. Surg. 2006;81:S2381-S2388.
ABSTRACT
| FULL TEXT
Overview of Heparin and Protamine Management and Dosing Regimens in Pediatric Cardiac Surgical Patients
Oliver
SEMIN CARDIOTHORAC VASC ANESTH 2003;7:387-410.
ABSTRACT
Heparin dose during percutaneous coronary intervention: how low dare we go?
Niccoli and Banning
Heart 2002;88:331-334.
ABSTRACT
| FULL TEXT
The Plasma Supplemented Modified Activated Clotting Time for Monitoring of Heparinization During Cardiopulmonary Bypass: A Pilot Investigation
Koster et al.
Anesth. Analg. 2002;95:26-30.
ABSTRACT
| FULL TEXT
|
