Antioxidants in Critical Illness
Eileen M. Bulger, MD;
Ronald V. Maier, MD
Arch Surg. 2001;136:1201-1207.
Oxidative stress has been implicated in the manifestations of critical illnesses, including ischemia and reperfusion injury and systemic inflammatory states. This review describes the evidence for increased oxidative stress in critically ill patients and explores the data regarding antioxidant therapy for these conditions. Antioxidant therapies reviewed include N-acetylcysteine, selenium, vitamins E and C, superoxide dismutase, catalase, lazaroids, and allopurinol. We focus on the results of these interventions in animal models and human trials, when available.
From the Department of Surgery, Harborview Medical Center, Seattle, Wash.
RELATED ARTICLE
This Month in Archives of Surgery
Arch Surg. 2001;136(10):1105.
FULL TEXT
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Impact of High-Dose Antioxidants on Outcomes in Acutely Injured Patients
Collier et al.
JPEN J Parenter Enteral Nutr 2008;32:384-388.
ABSTRACT
| FULL TEXT
Antioxidant Micronutrients in Major Trauma and Burns: Evidence and Practice
Berger
Nutr Clin Pract 2006;21:438-449.
ABSTRACT
| FULL TEXT
Introduction: The Scientific Basis for Injury Control
Rivara
Epidemiol Rev 2003;25:20-23.
FULL TEXT
Is Combined Partial Hepatectomy With Segmental Resection of Inferior Vena Cava Justified for Malignancy?
Sarmiento et al.
Arch Surg 2003;138:624-631.
ABSTRACT
| FULL TEXT
Abnormal Uterine Bleeding during Progestin-Only Contraception May Result from Free Radical-Induced Alterations in Angiopoietin Expression
Krikun et al.
Am. J. Pathol. 2002;161:979-986.
ABSTRACT
| FULL TEXT
|
