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Increased Rate of Infection Associated With Transfusion of Old Blood After Severe Injury
Patrick J. Offner, MD, MPH;
Ernest E. Moore, MD;
Walter L. Biffl, MD;
Jeffrey L. Johnson, MD;
Christopher C. Silliman, MD, PhD
Arch Surg. 2002;137:711-717.
Hypothesis Blood components undergo changes during storage that may affect the recipient, including the release of bioactive agents, with significant immune consequences. We hypothesized that transfusion of old blood increases infection risk in severely injured patients.
Design Prospective cohort study.
Setting Urban level I regional trauma center.
Patients Sixty-one trauma patients with an Injury Severity Score greater than 15, age older than 15 years, and survival longer than 48 hours who were transfused with 6 to 20 U of red blood cells in the first 12 hours after injury were studied. By means of blood bank records, the age of each unit of blood was determined.
Intervention Transfusion of allogeneic red blood cells.
Main Outcome Measurements Major infectious complications.
Results The early (<12 hours) transfusion requirement was 12 ± 0.6 U, with a mean age 27 ± 1 days. Major infections developed in 32 patients (52%). Age and Injury Severity Score were not significantly different between patients who developed infections and those who did not (age, 39 ± 4 vs 36 ± 3 years; Injury Severity Score, 33 ± 1.5 vs 29 ± 1.5). Transfusion of older blood was associated with subsequent infection; patients who developed infections received 11.7 ± 1.0 and 9.9 ± 1.0 U of red blood cells older than 14 and 21 days, respectively, compared with 8.7 ± 0.8 and 6.7 ± 0.08 in patients who did not develop infections (both P<.05, t test). Multivariate analysis confirmed age of blood as an independent risk factor for major infections.
Conclusions Transfusion of old blood is associated with increased infection after major injury. Other options, such as leukocyte-depleted blood or blood substitutes, may be more appropriate in the early resuscitation of trauma patients requiring transfusion.
From the Trauma Service, St Anthony Central Hospital (Dr Offner), and Department of Surgery, Denver Health Medical Center (Drs Moore, Biffl, Johnson, and Silliman) Denver, Colo.
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