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O. Glehen, MD; V. Schreiber, MD; E. Cotte, MD; A. C. Sayag-Beaujard, MD; D. Osinsky, MD; G. Freyer, MD, PhD; Y. François, MD; J. Vignal, MD; F. N. Gilly, MD, PhD

Arch Surg. 2004;139:20-26.

Hypothesis  The most common cause of palliative resection and recurrence in gastric cancer is peritoneal seeding. This study evaluates the efficacy of intraperitoneal chemohyperthermia after cytoreductive surgery in patients with peritoneal carcinomatosis arising from gastric cancer.

Design  Prospective clinical trial.

Setting  Surgical department at a university academic hospital.

Patients  Forty-nine consecutive patients with peritoneal carcinomatosis treated between January 1, 1989, and February 29, 2000.

Interventions  All patients underwent intraperitoneal chemohyperthermia with mitomycin C (40-60 mg); 21 patients had previously undergone extensive cytoreductive surgery.

Main Outcome Measures  Clinicopathologic factors that affect overall survival rates.

Results  With median follow-up of 99 months, overall median survival was 10.3 months. Two factors were significant independent predictors of survival by multivariate analysis: preoperative ascites (P = .04) and completeness of cancer resection (CCR) by cytoreductive surgery (P<.001). Median survival was 21.3 months for patients with CCR-0 (macroscopic complete resection) or CCR-1 (diameter of residual nodules <5 mm) and 6.1 months for patients with CCR-2 (diameter of residual nodules >5 mm) (P<.001). Four patients survived longer than 5 years.

Conclusions  An aggressive management strategy combining intraperitoneal chemohyperthermia with cytoreductive surgery is effective for patients with peritoneal carcinomatosis arising from gastric cancer. In highly selected patients (good general status, resectable primary tumor, resectable peritoneal carcinomatosis), this therapy may result in long-term survival.

From the Departments of Surgery (Drs Glehen, Osinsky, François, Vignal, and Gilly), Intensive Care (Dr Sayag-Beaujard), and Oncology (Dr Freyer), Centre Hospitalier Lyon-Sud, Pierre Bénite; and the Oncologic Hyperthermia Laboratory-EA Ciblage thérapeutique en Oncologie, Université CB Lyon-1, Oullins (Drs Glehen, Schreiber, Cotte, and Gilly), France.

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