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Ronnie T. P. Poon, FRCS(Edin); Kelvin K. C. Ng, FRCSEd(Gen); Chi-Ming Lam, FRCS(Edin); Victor Ai, FRCR; Jimmy Yuen, FRCR; Sheung-Tat Fan, MD, PhD, FRCS(Edin& Glasg)

Arch Surg. 2004;139:281-287.

Hypothesis  Radiofrequency ablation is a safe and effective treatment for hepatocellular carcinomas 3.1 to 8.0 cm in diameter.

Design  Case series with prospective data collection.

Setting  Tertiary referral center.

Patients  Eighty-six patients with hepatocellular carcinoma treated with radiofrequency ablation from May 1, 2001, to December 31, 2002, were placed into categories of those with tumors 3 cm or smaller (group 1, n = 51) and those with tumors 3.1 to 8.0 cm (group 2, n = 35) in diameter.

Interventions  Radiofrequency ablation was performed with a single or cluster cool-tip electrode. The choice of treatment route was based on tumor size and position.

Main Outcome Measures  Complication, treatment mortality, and complete ablation rates.

Results  Radiofrequency ablation was performed percutaneously in 26 patients in group 1 and 9 patients in group 2, with laparoscopy in 2 patients in group 1 and 1 patient in group 2, and with open operation in 23 patients in group 1 and 25 patients in group 2. The complication rates were 12% and 17% in group 1 and group 2, respectively (P = .48); treatment mortality rates were 0% and 3%, respectively (P = .41). Complete ablation rates after a single session of ablation assessed by means of computed tomography 1 month after treatment were 94% and 91% in group 1 and group 2, respectively (P = .68).

Conclusion  Radiofrequency ablation is a safe and effective treatment for patients with hepatocellular carcinomas 3.1 to 8.0 cm in diameter.

From the Centre for the Study of Liver Disease and Departments of Surgery (Drs Poon, Ng, Lam, and Fan) and Radiology (Drs Ai and Yuen), University of Hong Kong Medical Centre, Queen Mary Hospital, Pokfulam, Hong Kong, People's Republic of China.

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