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George D. Bablekos, MD, PhD; Stylianos A. Michaelides, MD; Trianthi Roussou, MD; Konstantinos A. Charalabopoulos, MD, PhD

Arch Surg. 2006;141:16-22.

Hypothesis  We hypothesized that there might be different effects on breathing control and respiratory mechanics after laparoscopic vs open cholecystectomy.

Design  Randomized clinical trial.

Setting  A general hospital in Greece.

Patients  Of 53 patients assessed for eligibility, 18 and 10 were randomly allocated to the laparoscopic and open cholecystectomy groups, respectively. These 28 patients had normal spirometry measurements and American Society of Anesthesiologists’ class I physical status.

Main Outcome Measures  Measurements of breathing control and mechanics variables. Tidal volume, inspiratory time, breathing frequency, mean inspiratory flow, duty cycle, central respiratory drive, and mean inspiratory impedance were recorded before surgery on the second and eighth postoperative days. Airway resistance was recorded before surgery and on the eighth postoperative day, with all measurements being performed under no influence of analgesia.

Results  Two days after surgery, inspiratory time, breathing frequency, and central respiratory drive were significantly changed compared with preoperative values for both methods, whereas mean inspiratory impedance was significantly increased (P<.001) for the laparoscopic procedure. Eight days after surgery, changes were seen only for the laparoscopic group: duty cycle and airway resistance were significantly reduced (P = .01) and increased (P = .04), respectively, compared with preoperative data.

Conclusion  Laparoscopic cholecystectomy seems to be associated with small but sustained alterations in the control of breathing and mechanics, which might have an unfavorable clinical impact on patients with compromised lung function.

Author Affiliations: Department of Experimental Physiology, Faculty of Medicine, University of Athens (Dr Bablekos), First Thoracic Surgical Department, Hippokration General Hospital (Dr Bablekos), Department of Thoracic Medicine, Amalia Fleming Memorial Hospital (Dr Michaelides), Department of Respiratory Medicine, Henri Dunan Hospital (Dr Roussou), Athens, and Department of Experimental Physiology, Clinical Unit, Faculty of Medicine, University of Ioannina, Ioannina (Dr Charalabopoulos), Greece.

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