• Online Features  This Article  • Full text  • PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (23)  • Contact me when this article is cited  Related Content  • Related letter  • Similar articles in this journal  Topic Collections  • Oncology  • Colon Cancer  • Oncology, Other  • Radiation Therapy  • Surgery  • Surgery, Other  • Review  • Gastroenterology  • Gastrointestinal Diseases  • Liver/ Biliary Tract/ Pancreatic Diseases  • Alert me on articles by topic  Social Bookmarking   What's this?

Seza A. Gulec, MD; Yuman Fong, MD

Arch Surg. 2007;142(7):675-682.

Objective  To discuss the basic concepts involved in the development of yttrium 90 (Y-90) microsphere selective internal radiation treatment and review the clinical data pertaining to its application in hepatic colorectal cancer metastases.

Data Sources  Published studies and scientific paper presentations.

Study Selection  Randomized clinical studies and retrospective reviews.

Conclusions  Selective internal radiation treatment is a promising new modality in the treatment of patients with hepatic colorectal cancer metastases as part of a multimodality approach. A chemo–selective internal radiation treatment neoadjuvant approach has a potential to improve therapeutic outcomes. Clinical studies in neoadjuvant and salvage settings are needed for more concrete outcome data and design of optimal multimodality treatment strategies.

Author Affiliations: Center for Cancer Care at Goshen Health System, Goshen, Indiana (Dr Gulec); and Memorial Sloan Kettering Cancer Center, New York, New York (Dr Fong)

CiteULike    Connotea    Delicious    Digg    Facebook    Reddit    Technorati    Twitter     What's this?

RELATED LETTER

Yttrium 90 Microsphere Selective Internal Radiation Treatment of Hepatic Colorectal Metastases
Timothy J. Price and Amanda Townsend
Arch Surg. 2008;143(3):313-314.
EXTRACT | FULL TEXT  

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Colorectal liver metastases
Sutcliffe and Bhattacharya
Br Med Bull 2011;99:107-124.
ABSTRACT | FULL TEXT  

Clinical features and treatment outcomes of advanced stage primary hepatic angiosarcoma
Kim et al.
Ann Oncol 2009;20:780-787.
ABSTRACT | FULL TEXT  

Yttrium 90 Microsphere Selective Internal Radiation Treatment of Hepatic Colorectal Metastases
Price and Townsend
Arch Surg 2008;143:313-314.
FULL TEXT  

Posttherapy Radiation Safety Considerations in Radiomicrosphere Treatment with 90Y-Microspheres
Gulec and Siegel
JNM 2007;48:2080-2086.
ABSTRACT | FULL TEXT