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Long-term Outcome of Patients With Elevated Parathyroid Hormone Levels After Successful Parathyroidectomy for Sporadic Primary Hyperparathyroidism
Carmen C. Solorzano, MD;
William Mendez, MD;
John I. Lew, MD;
Steven E. Rodgers, MD, PhD;
Raquel Montano, BS;
Denise M. Carneiro-Pla, MD;
George L. Irvin III, MD
Arch Surg. 2008;143(7):659-663.
Hypothesis Untreated long-term elevated parathyroid hormone (PTH) levels after successful parathyroidectomy may predict recurrent hyperparathyroidism (HPT). Although elevated PTH levels have been reported in eucalcemic patients after parathyroidectomy for sporadic primary HPT, the long-term clinical significance of this finding remains unclear.
Design Retrospective case series.
Setting Tertiary referral center.
Patients Five hundred seventy-six consecutive patients with HPT.
Intervention Parathyroidectomy guided by intraoperative monitoring of PTH levels.
Main Outcome Measures Overall incidence of elevated PTH levels (measurements of  70 pg/mL at any time during follow-up) and recurrent HPT (hypercalcemia and elevated PTH levels more than 6 months after parathyroidectomy).
Results Of the 505 patients who underwent successful parathyroidectomy in this series and were followed up for more than 6 months, 337 (66.7%) consistently had PTH levels within the reference range, and 168 (33.3%) had elevated PTH levels. Of the 168 patients with elevated PTH levels, only 8 (4.8%) developed recurrent disease. The earliest recurrence occurred 2 years postoperatively. Factors associated with elevated PTH levels included advanced age, higher preoperative PTH levels, and mild postoperative renal insufficiency.
Conclusion Although one-third of the patients had elevated PTH levels after successful parathyroidectomy, most of these patients with elevated PTH levels (95%) will achieve long-term eucalcemia.
Author Affiliations: Division of Endocrine Surgery, DeWitt Daughtry Family Department of Surgery, University of Miami Miller School of Medicine, Miami, Florida (Drs Solorzano, Mendez, Lew, Rodgers, and Irvin and Ms Montano); and Departments of Surgery, University of Puerto Rico School of Medicine, San Juan (Dr Mendez) and Medical University of South Carolina, Charleston (Dr Carneiro-Pla).
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