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Courtney M. Townsend, MD
The University of Texas Medical Branch
Galveston

Arch Surg. 1998;133:17.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

The original report by Stabile et al¹ that the gastrinoma triangle harbored most sporadic gastrinomas was a seminal clinical observation. Its importance to the study of gastrointestinal endocrine tumors is no less than that of William Beaumont to gastric physiology. From the observation that most sporadic (nonhereditary, ie, multiple endocrine neoplasia type I) gastrinomas occurred in the gastrinoma triangle, these investigators have continued to examine this phenomenon. They have removed the mystery from the "ectopic" gastrinomas. The mystery sprung from the false concept that all gastrinomas should arise in the pancreas; the original patients had pancreatic neoplasms. No gastrin-containing cells can be identified in the adult human pancreas. The authors' work has been hampered by the relative rarity of these tumors and the inability to conduct a prospective randomized trial. However, their prescient observation and persistent examination have led them to their current description.² Passaro et . . . [Full Text of this Article]

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The Origin of Sporadic Gastrinomas Within the Gastrinoma Triangle: A Theory
Edward Passaro, Jr, Thomas J. Howard, Mark P. Sawicki, Philip C. Watt, and Bruce E. Stabile
Arch Surg. 1998;133(1):13-16.
ABSTRACT | FULL TEXT