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Apoptosis: Programmed Cell Death
Nai-Kang Kuan, BS;
Edward Passaro, Jr, MD
Arch Surg. 1998;133:773-775.
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INTRODUCTION
Currently there is much interest and excitement in the understanding of how cells undergo the process of apoptosis or programmed cell death. Understanding how, why, and when cells are instructed to die may provide insight into the aging process, autoimmune syndromes, degenerative diseases, and malignant transformation. This review focuses on the development of apoptosis and describes the process of programmed cell death, some of the factors that incite or prevent its occurrence, and finally some of the diseases in which it may play a role. The hope is that in the not too distant future we may be able to modify or thwart the apoptotic process for therapeutic benefit.
The notion that cells are eliminated or absorbed in an orderly manner is not new. What is new is the recognition that this is an important physiologic process.1 More than 40 years ago embryologists . . . [Full Text of this Article]
APOPTOSIS VS NECROSIS
APOPTOSIS AND HOMEOSTASIS
MECHANISM OF APOPTOSIS
APOPTOSIS AND DISEASE
From the Department of Toxicology, University of Cincinnati, Cincinnati, Ohio (Mr Kuan); and the Department of Surgery, West Los Angeles Veterans Affairs Medical Center (Dr Passaro), Los Angeles, Calif.
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