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Christian Herfarth, MD
Heidelberg, Germany

Arch Surg. 2000;135:88.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

A prospective uncontrolled study on preoperative chemoradiotherapy in patients with locally advanced pancreatic cancer is presented. The neoadjuvant therapeutic regimen consisted of fluorouracil, 400 mg/m², and cisplatin, 25 mg/m², along with concurrent radiation of 45 Gy. Patients were surgically staged prior to the neoadjuvant regimen and had biliary along with gastric bypass as well as a feeding jejunostomy tube placed. Of 14 patients, 11 underwent reexploration. Two of these 11 patients had progressive disease that was unresectable; 9 had definitive resections, 6 of whom had either portal vein or major arterial resections. There was 1 hospital death and 1 long-term survivor (>96 months). Median survival was 16 months after definitive surgery.

Although this study represents another valuable effort to improve the prognosis of patients with pancreatic cancer, even after potentially curative resection, a number of concerns remain. It is stated that only patients with locally . . . [Full Text of this Article]

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