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Ronald V. Maier, MD
Seattle, Wash

Arch Surg. 2000;135:1314.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Dr Wick and colleagues add welcome data to ongoing evaluations of the immunologic effects of severe injury. Using a refined flow cytometric analysis, these investigators further define the effects of blunt trauma on the pattern and function of circulating lymphocytes: T_H1 vs T_H2 CD3⁺ cells. Prior studies have produced extremely variable results in the shift from T_H1 to T_H2 phenotype consistent with an increased risk for infectious and other immunologic complications.

A major contribution of the current data is the appropriate warning that previous results derived from either artifactually defined murine models or highly selected aspects of alterations in humans are insufficient and potentially harmful if extrapolated to deriving therapeutic targets for clinical trials. While the study confirms a decrease in the CD3⁺ T-lymphocyte population, there was no statistically significant shift in T_H1 to T_H2 phenotype or concomitant shift in . . . [Full Text of this Article]

RELATED ARTICLE

The Potential Pattern of Circulating Lymphocytes T_H1/T_H2 Is Not Altered After Multiple Injuries
Marc Wick, Erwin Kollig, Gert Muhr, and Manfred Köller
Arch Surg. 2000;135(11):1309-1314.
ABSTRACT | FULL TEXT