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Impact of Histological Grade of Hepatocellular Carcinoma on the Outcome of Liver Transplantation—Invited Response
Sumihito Tamura, MD;
Tomoaki Kato, MD;
Rajander Reddy, MD;
Andreas Tzakis, MD
Miami, Fla
Arch Surg. 2001;136:31.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. |
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We agree with Dr Selby regarding the predictive value of major vascular invasion. We also use noninvasive imaging techniques extensively and consider major vascular invasion an absolute contraindication to liver transplantation. Even so, major vascular invasion was observed in the explanted livers of 6 of our patients.
Four patients had poorly differentiated tumors and 2 had well- to moderately differentiated tumors (data not included in the text). We did perform a multivariate analysis excluding pTNM stage, and major vascular invasion was not a statistically significant independent factor in either patient survival or tumor recurrence analysis, although it showed statistical significance in univariate analysis.
Our findings reinforce an earlier observation of a multicenter study,1 which suggested that the histologic grade of the tumor is an independent predictive factor of patient outcome. Our findings may not be universally applicable at . . . [Full Text of this Article]
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