I read with great interest the study by Meek et al1 in which they concluded that a serum glucose concentration of at least 150 mg/dL (8.3 mmol/L) is the best predictor of complications of gallstone pancreatitis. I have some reservations regarding their conclusions.
A variable that differs significantly between mild and severe pancreatitis is not necessarily a good predictor of severity.2 Serum glucose concentration is not a good predictor simply because its positive predictive value (41%) is low. This means that 60% of patients labeled severe according to this variable actually have mild pancreatitis. The false-positive results are too high.
The authors define the complications as severe if the patient was in the intensive care unit (ICU) for more than 24 hours.1 Some patients with severe pancreatitis are treated outside of the ICU because of their morbid condition or a lack of beds. A prolonged stay in the ICU may . . . [Full Text of this Article]