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Human Immunodeficiency Virus and Malignancy
Thoughts on Viral Oncogenesis
William P. Schecter, MD
Arch Surg. 2001;136:1419-1425.
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INTRODUCTION
In the spring of 1981, as a newly minted assistant professor of surgery at the University of California–San Francisco, I was called to see a 33-year-old man with bilateral interstitial pulmonary infiltrates who was dying of acute respiratory failure at San Francisco General Hospital. My medical colleagues requested an open-lung biopsy. To our mutual amazement, this previously healthy gay man had Pneumocystis carinii pneumonia, despite the fact that there was no history of lymphoma or organ transplantation. The first cluster of cases of this pneumonia was reported the same year.1
At approximately the same time, a previously rare tumor, Kaposi sarcoma (KS), began to appear in epidemic numbers, first reported in Los Angeles, Calif, and New York, NY.2 By 1983, Luc Montagnier had discovered an RNA retrovirus associated with the disease complex occurring primarily in gay men, which had been termed the acquired immune deficiency syndrome . . . [Full Text of this Article]
HISTORY
ANATOMY OF HIV
CELL-CYCLE PROGRESSION
EFFECT OF VIRAL INFECTION ON CELL-CYCLE CONTROL
CONCLUSIONS
From the Department of Surgery, University of California–San Francisco.
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Int J STD AIDS 2008;19:611-616.
ABSTRACT
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