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Serum Levels of Transforming Growth Factor 1 in Patients With Breast Cancer—Invited Critique

Edgar D. Staren, MD, PhD
Toledo, Ohio

Arch Surg. 2001;136:940.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Transforming growth factor is a member of a superfamily of polypeptides with diverse and complex biological functions. The report by Sheen-Chen et al suggests an association between serum expression of TGF- and breast cancer stage and grade of disease. However, as noted by the authors, analyses of the relationship between TGF- and breast cancer have previously resulted in a number of conflicting reports.^1-4 In fact, this study demonstrated no difference in TGF- expression in patients with benign breast disease compared with patients with breast cancer. Some reports have demonstrated results completely contrary to the present report, finding decreased TGF- serum expression, while others have reported results similar to that of Sheen-Chen et al, that decreased TGF- receptor expression is associated with more advanced breast cancer. These latter studies seem more consistent with the well-recognized growth inhibitory effect of TGF- on normal mammary epithelial cells. Such . . . [Full Text of this Article]

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Serum Levels of Transforming Growth Factor 1 in Patients With Breast Cancer
Shyr-Ming Sheen-Chen, Han-Shiang Chen, Chih-Wei Sheen, Hock-Liew Eng, and Wei-Jen Chen
Arch Surg. 2001;136(8):937-940.
ABSTRACT | FULL TEXT