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Stephen F. Lowry, MD
New Brunswick, NJ

Arch Surg. 2002;137:1043.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Modern surgical therapy can restore function to most patients, including many with disabling maladies. Yet, what is there about the presence of infection in these patients that occasionally leads to multiple organ failure and poor outcome?

Once patients become severely infected, their demographics for adverse outcome (age, sex, comorbidities, etc) are reasonably well captured by severity scoring systems. The report by Cabioglu et al supports this concept. Their article also reiterates the theme that outcome prediction can be enhanced (almost in real time) by the analysis of immune cell phenotype. Although their results are at some variance with those of previous reports in this journal,^1-2 Cabioglu and colleagues surmise that adverse clinical outcome correlates with an attenuation of immune cell proinflammatory mediator influence (T_H1) compared with the T_H2 phenotype. Unfortunately, the authors neither address the methodological and data variances from previous reports nor provide . . . [Full Text of this Article]

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Arch Surg. 2002;137(9):1037-1043.
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